Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity
文献类型：期刊论文
| 作者 | Yen, Chia-I1; Liu, Szu-Mam2; Lo, Wei-Shang1; Wu, Jhe-Wei1; Liu, Yi-Hsin1; Chein, Rong-Jie3; Yang, Renqiang4; Wu, Kevin C. -W.5; Hwu, Jih Ru6,7; Ma, Nianhan2 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2016-02-24 |
| 卷号 | 22期号:9页码:2925-2929 |
| 关键词 | cytotoxicity drug carriers metal-organic frameworks post-modification ZIF-90 |
| 英文摘要 | Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated-ZIF-90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 has a higher cytotoxicity of about 30gmL(-1). |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | METAL-ORGANIC-FRAMEWORK ; DRUG-DELIVERY ; SURFACE FUNCTIONALITY ; CELLULAR UPTAKE ; NANOPARTICLES ; CANCER ; SIZE ; SILICA ; NANOARCHITECTONICS ; CARRIERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000370452300012 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/8017]  |
| 专题 | 青岛生物能源与过程研究所_先进有机功能材料团队 |
| 作者单位 | 1.Natl Cent Univ, Dept Chem, Taoyuan 32001, Taiwan 2.Natl Cent Univ, Inst Syst Biol & Bioinformat, Dept Biomed Sci & Engn, Taoyuan 32001, Taiwan 3.Acad Sinica, Inst Chem, Taipei 11529, Taiwan 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 5.Natl Taiwan Univ, Dept Chem Engn, Taipei 10617, Taiwan 6.Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan 7.Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan |
| 推荐引用方式 GB/T 7714 | Yen, Chia-I,Liu, Szu-Mam,Lo, Wei-Shang,et al. Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity[J]. CHEMISTRY-A EUROPEAN JOURNAL,2016,22(9):2925-2929. |
| APA | Yen, Chia-I.,Liu, Szu-Mam.,Lo, Wei-Shang.,Wu, Jhe-Wei.,Liu, Yi-Hsin.,...&Shieh, Fa-Kuen.(2016).Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity.CHEMISTRY-A EUROPEAN JOURNAL,22(9),2925-2929. |
| MLA | Yen, Chia-I,et al."Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity".CHEMISTRY-A EUROPEAN JOURNAL 22.9(2016):2925-2929. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。