Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth
文献类型：期刊论文
| 作者 | Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Yan, Linyin3; Ma, Guanghui3; Liu, Lei4; Dai, Luru5; Li, Junbai5; Moehwald, Helmuth6; Yan, Xuehai3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2015-11-11 |
| 卷号 | 7期号:44页码:24733-24740 |
| 关键词 | collagen protein colloidal gold nanoparticles core-shell nanoconjugates layer-by-layer assembly cell adhesion and growth |
| ISSN号 | 1944-8244 |
| 英文摘要 | The biogenic synthesis of biomolecule-gold nanoconjugates is of key importance for a broad range of biomedical applications. In this work, a one-step, green, and condition-gentle strategy is presented to synthesize stable colloidal-gold collagen core-shell nanoconjugates in an aqueous solution at room temperature, without use of any reducing agents and stabilizing agents. It is discovered that electrostatic binding between gold ions and collagen proteins and concomitant in situ reduction by hydroxyproline residues are critically responsible for the formation of the core shell nanoconjugates. The film formed by layer-by-layer assembly of such colloidal gold-collagen nanoconjugates can notably improve the mechanical properties and promote cell adhesion, growth, and differentiation. Thus, the colloidal gold-collagen nanoconjugates synthesized by such a straightforward and clean manner, analogous to a biomineralization pathway, provide new alternatives for developing biologically based hybrid biomaterials toward a range of therapeutic and diagnostic applications. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | ONE-POT SYNTHESIS ; MECHANICAL-PROPERTIES ; METAL NANOPARTICLES ; FUNCTIONALIZATION ; IMMOBILIZATION ; TRANSFECTION ; BIOLOGY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364726400041 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/19861]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Jiangsu Univ, Inst Adv Mat, Zhenjiang 212013, Jiangsu, Peoples R China 5.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 6.Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany |
| 推荐引用方式 GB/T 7714 | Xing, Ruirui,Jiao, Tifeng,Yan, Linyin,et al. Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(44):24733-24740. |
| APA | Xing, Ruirui.,Jiao, Tifeng.,Yan, Linyin.,Ma, Guanghui.,Liu, Lei.,...&Yan, Xuehai.(2015).Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth.ACS APPLIED MATERIALS & INTERFACES,7(44),24733-24740. |
| MLA | Xing, Ruirui,et al."Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth".ACS APPLIED MATERIALS & INTERFACES 7.44(2015):24733-24740. |
入库方式： OAI收割
来源：过程工程研究所
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