Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications
文献类型：期刊论文
| 作者 | Yue, Hua1; Ma, Guanghui1,2 |
| 刊名 | VACCINE
 |
| 出版日期 | 2015-11-04 |
| 卷号 | 33期号:44页码:5927-5936 |
| 关键词 | Micro/nanoparticles Adjuvant Physiochemical property Preventive/therapeutic vaccine Antigen loading Immunological mechanism |
| ISSN号 | 0264-410X |
| 英文摘要 | Particle based adjuvant showed promising signs on delivering antigen to immune cells and acting as stimulators to elicit preventive or therapeutic response. Nevertheless, the wide size distribution of available polymeric particles has so far obscured the immunostimulative effects of particle adjuvant, and compromised the progress in pharmacological researches. To conquer this hurdle, our research group has carried out a series of researches regarding the particulate vaccine, by taking advantage of the successful fabrication of polymeric particles with uniform size. In this review, we highlight the insight and practical progress focused on the effects of physiochemical property (e.g. particle size, charge, hydrophobicity, surface chemical group, and particle shape) and antigen loading mode on the resultant biological/immunological outcome. The underlying mechanisms of how the particles-based vaccine functioned in the immune system are also discussed. Based on the knowledge, particles with high antigen payload and optimized attributes could be designed for expected adjuvant purpose, leading to the development of high efficient vaccine candidates. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Immunology ; Research & Experimental Medicine |
| 关键词[WOS] | MEMBRANE EMULSIFICATION TECHNIQUE ; THERAPEUTIC CANCER VACCINES ; T-CELL RESPONSES ; IMMUNE-RESPONSES ; DRUG-DELIVERY ; NANOPARTICLE VACCINES ; BIODEGRADABLE NANOPARTICLES ; CHITOSAN MICROSPHERES ; COMPLEMENT ACTIVATION ; SENSITIVE HYDROGEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000365365700007 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/19904]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Hua,Ma, Guanghui. Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications[J]. VACCINE,2015,33(44):5927-5936. |
| APA | Yue, Hua,&Ma, Guanghui.(2015).Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications.VACCINE,33(44),5927-5936. |
| MLA | Yue, Hua,et al."Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications".VACCINE 33.44(2015):5927-5936. |
入库方式： OAI收割
来源：过程工程研究所
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