Oxygen-dependent hyperpolarized Xe-129 brain MR
文献类型：期刊论文
| 作者 | Li, Haidong; Zhang, Zhiying; Zhong, Jianping; Ruan, Weiwei; Han, Yeqing; Sun, Xianping; Ye, Chaohui; Zhou, Xin |
| 刊名 | NMR IN BIOMEDICINE
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 29期号:3页码:220-225 |
| 关键词 | hyperpolarized Xe-129 brain MRI oxygen concentration SEOP |
| 英文摘要 | Hyperpolarized (HP) Xe-129 MR offers unique advantages for brain functional imaging (fMRI) because of its extremely high sensitivity to different chemical environments and the total absence of background noise in biological tissues. However, its advancement and applications are currently plagued by issues of signal strength. Generally, xenon atoms found in the brain after inhalation are transferred from the lung via the bloodstream. The longitudinal relaxation time (T-1) of HP Xe-129 is inversely proportional to the pulmonary oxygen concentration in the lung because oxygen molecules are paramagnetic. However, the T-1 of Xe-129 is proportional to the pulmonary oxygen concentration in the blood, because the higher pulmonary oxygen concentration will result in a higher concentration of diamagnetic oxyhemoglobin. Accordingly, there should be an optimal pulmonary oxygen concentration for a given quantity of HP Xe-129 in the brain. In this study, the relationship between pulmonary oxygen concentration and HP Xe-129 signal in the brain was analyzed using a theoretical model and measured through in vivo experiments. The results from the theoretical model and experiments in rats are found to be in good agreement with each other. The optimal pulmonary oxygen concentration predicted by the theoretical model was 21%, and the in vivo experiments confirmed the presence of such an optimal ratio by reporting measurements between 25% and 35%. These findings are helpful for improving the Xe-129 signal in the brain and make the most of the limited spin polarization available for brain experiments. Copyright (c) 2016 John Wiley & Sons, Ltd. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 研究领域[WOS] | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 关键词[WOS] | LASER-POLARIZED XE-129 ; MAGNETIC-RESONANCE ; BLOOD ; RAT ; GAS ; SPECTROSCOPY ; NMR ; DELIVERY ; XENON ; FLOW |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371426000001 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9215]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Haidong,Zhang, Zhiying,Zhong, Jianping,et al. Oxygen-dependent hyperpolarized Xe-129 brain MR[J]. NMR IN BIOMEDICINE,2016,29(3):220-225. |
| APA | Li, Haidong.,Zhang, Zhiying.,Zhong, Jianping.,Ruan, Weiwei.,Han, Yeqing.,...&Zhou, Xin.(2016).Oxygen-dependent hyperpolarized Xe-129 brain MR.NMR IN BIOMEDICINE,29(3),220-225. |
| MLA | Li, Haidong,et al."Oxygen-dependent hyperpolarized Xe-129 brain MR".NMR IN BIOMEDICINE 29.3(2016):220-225. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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