Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid
文献类型：期刊论文
| 作者 | Liu, Qingfen; Li, Yingbo; Li, Wangliang; Liang, Xiangfeng; Zhang, Chao; Liu, Huizhou |
| 刊名 | ACS SUSTAINABLE CHEMISTRY & ENGINEERING
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 4期号:2页码:609-615 |
| 关键词 | Penicillin G Ionic liquids Liquid-liquid extraction Partition coefficient Mechanism |
| ISSN号 | 2168-0485 |
| 英文摘要 | Penicillin G is a widely used antibiotic, but the traditional volatile organic solvent extraction causes serious environmental problems. In this work, a hydrophobic ionic liquid ([Bmim]PF6) was developed as a new extraction agent for recovery of penicillin G from aqueous solutions. The extraction efficiency and the partition coefficient of penicillin G were used as the indexes to evaluate the IL extraction ability. Key factors affecting the effectiveness of recovery, such as the pH of the aqueous solution, the initial concentration of penicillin G, and the IL-to-aqueous solution volume ratio, were investigated to determine the optimal conditions. The results showed that the pH of the aqueous phase strongly influenced the success of the extraction. The optimal pH value, phase ratio, and penicillin concentration were 1.5-2.0, 1.5/1 to 2.0/ 1, and 3.00-5.00 X 10(4) units/mL, respectively, whereby the partition coefficient and extraction efficiency were more than 30 and 91%, respectively. The extraction mechanism was explored by analyzing the chemical bonds using spectrographic analysis. Preliminary results indicated that penicillin G can be effectively extracted from fermentation broth by [Bmim]PF6 with extraction efficiencies of >87%. In addition, a higher selectivity and a much lower extent of emulsification were achieved by [Bmim]PF6 compared to those of butyl acetate. It demonstrates that the IL-based extraction strategy developed in this work is promising and effective, and as a result, the development of an IL-based extraction process for the recovery of penicillin G is straightforwardly envisaged. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Engineering, Chemical |
| 研究领域[WOS] | Chemistry ; Engineering |
| 关键词[WOS] | AQUEOUS 2-PHASE SYSTEM ; BETA-LACTAM ANTIBIOTICS ; FERMENTATION BROTH ; EXTRACTION ; SEPARATION ; SOLVENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369347800029 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/20612]  |
| 专题 | 过程工程研究所_湿法冶金清洁生产技术国家工程实验室 |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, 1 BeiErJie, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qingfen,Li, Yingbo,Li, Wangliang,et al. Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2016,4(2):609-615. |
| APA | Liu, Qingfen,Li, Yingbo,Li, Wangliang,Liang, Xiangfeng,Zhang, Chao,&Liu, Huizhou.(2016).Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,4(2),609-615. |
| MLA | Liu, Qingfen,et al."Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 4.2(2016):609-615. |
入库方式： OAI收割
来源：过程工程研究所
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