Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo
文献类型：期刊论文
| 作者 | Li, Tinghui1; Hou, Xiaobin2; Deng, Hong3; Zhao, Jingquan3; Huang, Naiyan4; Zeng, Jing4; Chen, Hongxia4; Gu, Ying4 |
| 刊名 | PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
 |
| 出版日期 | 2015 |
| 卷号 | 14期号:5页码:972-981 |
| 英文摘要 | Photodynamic therapy (PDT) has been successfully implemented as a treatment for wet age-related macular degeneration (AMD), but very few photosensitizers have been developed for clinical use. Herein, we describe a novel formulation of liposomal hypocrellin B (LHB) that was prepared by high-pressure homogenization. The encapsulation efficiency and PDT efficacy in vitro of this new preparation were found to remain nearly constant over 1 year. Moreover, LHB is rapidly cleared from the blood, with a half-life of 2.319 +/- 0.462 h and a very low serum concentration at 24 h after injection. Testing in a rat model of choroidal neovascularization (CNV) showed that leakage of blood vessels in CNV lesions was significantly reduced when LHB PDT was given at a dose of 1 mg kg(-1) along with yellow laser irradiation; the damage to the collateral retina and the retinal pigment epithelium was minimal. Skin phototoxicity assays showed that only two of the 200 mice given a 4 mg per kg dose of LHB experienced an inflammatory reaction in the auricle irradiated at 24 h after dosing. These data collectively indicate that LHB may be a safe and effective photosensitizer for vascular-targeted PDT of AMD. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28085]  |
| 专题 | 化学研究所_光化学实验室 |
| 作者单位 | 1.309 Hosp PLA, Dept Dermatol, Beijing 100091, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Thorac Surg, Beijing 100853, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Tinghui,Hou, Xiaobin,Deng, Hong,et al. Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo[J]. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,2015,14(5):972-981. |
| APA | Li, Tinghui.,Hou, Xiaobin.,Deng, Hong.,Zhao, Jingquan.,Huang, Naiyan.,...&Gu, Ying.(2015).Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo.PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,14(5),972-981. |
| MLA | Li, Tinghui,et al."Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo".PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 14.5(2015):972-981. |
入库方式： OAI收割
来源：化学研究所
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