A highly sensitive near-infrared ratiometric fluorescent probe for detecting nitroreductase and cellular imaging
文献类型：期刊论文
| 作者 | Zhu, Dongjian1,2; Xue, Lin2; Li, Guoping2; Jiang, Hua1 |
| 刊名 | SENSORS AND ACTUATORS B-CHEMICAL
 |
| 出版日期 | 2016 |
| 卷号 | 222页码:419-424 |
| 关键词 | Fluorescent probe Near-infrared Ratiometric Nitroreductase Cellular imaging |
| 英文摘要 | Based on the selective reduction of nitro group to hydroxylamine or amino group by nitroreductase in the presence of NADPH as an electron donor, a near-infrared ratiometric fluorescent probe CyNNO2 was designed and synthesized. CyNNO2 containing a p-nitrobenzyl moiety as a reactive group can selectively respond to nitroreductase with a ratiometric fluorescence signal output. The limit of detection for nitroreductase is 0.0058 ng/mL. Moreover, the probe can be used to image the endogenous nitroreductase in A549 cells under hypoxic condition. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29175]  |
| 专题 | 化学研究所_光化学实验室 |
| 作者单位 | 1.Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Dongjian,Xue, Lin,Li, Guoping,et al. A highly sensitive near-infrared ratiometric fluorescent probe for detecting nitroreductase and cellular imaging[J]. SENSORS AND ACTUATORS B-CHEMICAL,2016,222:419-424. |
| APA | Zhu, Dongjian,Xue, Lin,Li, Guoping,&Jiang, Hua.(2016).A highly sensitive near-infrared ratiometric fluorescent probe for detecting nitroreductase and cellular imaging.SENSORS AND ACTUATORS B-CHEMICAL,222,419-424. |
| MLA | Zhu, Dongjian,et al."A highly sensitive near-infrared ratiometric fluorescent probe for detecting nitroreductase and cellular imaging".SENSORS AND ACTUATORS B-CHEMICAL 222(2016):419-424. |
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来源：化学研究所
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