Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose
文献类型：期刊论文
| 作者 | Wang, Lu-Liang1,2,3,4,5; Qiao, Juan3,4,5; Qi, Li3,4,5; Xu, Xiao-Zhe6; Li, Dan1,2 |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 58期号:9页码:1508-1514 |
| 关键词 | AuNCs Ovalbumin GOx glucose fluorescence |
| 英文摘要 | Protein protected gold nanoclusters have outstanding physical and chemical properties that make them excellent scaffolds for the construction of novel chemical and biological probes. In this study, a simple one-pot synthesis method was proposed for the preparation of fluorescent probes based on ovalbumin-stabilized gold nanoclusters. This strategy allowed the generation of water-soluble gold nanoclusters within 5 min. The as-prepared fluorescent probe exhibited a red fluorescence emission at 625 nm, and good thermostability. The fluorescent probe was applied to measure glucose concentrations based on the hydrogen peroxide-induced fluorescence quenching principle, and showed favorable biocompatibility, high sensitivity and good selectivity. As a result of the advantageous properties and performance of this fluorescent probe, the present assay allowed for the selective determination of glucose in the range of 5.0x10(-6) to 10.0x10(-3) mol/L with a detection limit of 1.0x10(-6) mol/L. Moreover, the glucose content in urinary samples was analyzed using the constructed fluorescent probe: this indicated the potential of the fluorescent gold nanoclusters for applications in biological and clinical diagnosis and therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27645]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Shantou Univ, Dept Chem, Shantou 515063, Peoples R China 2.Shantou Univ, Res Inst Biomed & Adv Mat, Shantou 515063, Peoples R China 3.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 6.Tianjin Normal Univ, Coll Chem, Tianjin 300387, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lu-Liang,Qiao, Juan,Qi, Li,et al. Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose[J]. SCIENCE CHINA-CHEMISTRY,2015,58(9):1508-1514. |
| APA | Wang, Lu-Liang,Qiao, Juan,Qi, Li,Xu, Xiao-Zhe,&Li, Dan.(2015).Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose.SCIENCE CHINA-CHEMISTRY,58(9),1508-1514. |
| MLA | Wang, Lu-Liang,et al."Construction of OVA-stabilized fluorescent gold nanoclusters for sensing glucose".SCIENCE CHINA-CHEMISTRY 58.9(2015):1508-1514. |
入库方式： OAI收割
来源：化学研究所
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