Catalase Nanocapsules Protected by Polymer Shells for Scavenging Free Radicals of Tobacco Smoke
文献类型：期刊论文
| 作者 | Liu, Lizhi1,2; Yu, Wei1; Luo, Dan1; Xue, Zhenjie1; Qin, Xiaoyun1; Sun, Xiaohua1; Zhao, Jincai3; Wang, Jianlong2; Wang, Tie1 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2015-08-26 |
| 卷号 | 25期号:32页码:5159-5165 |
| 关键词 | catalase core-shell structures free radicals nanocapsules polymer shells tobacco smoke |
| 英文摘要 | Free radicals in tobacco smoke trigger numerous lung diseases, which are worldwide health considerations. The ideal free-radical, tobacco-smoke scavenger must be highly reactive and temperature resistant. Catalases (CATs) show attractive potential to scavenge free radicals in tobacco smoke, because of their higher reaction rate compared to that of non-catalyzed reactions. Their fragile nature, however, diminishes their catalytic activity in hot tobacco smoke. Therefore, it is essential to enhance the structural integrity and catalytic stability of these enzymes under severe environmental conditions. In order to improve the thermal stability of CATs, we have developed a facile approach to produce CAT nanocapsules (nCATs) by encapsulating a single enzyme in a polyacrylamide (PAAM) shell. The rigid polymer shells on the CATs surface prevents their free deformation. The secondary structure of the enzyme is retained and their dissociation is almost nil even under high operational temperatures. As a result, the structural stability and thermal resistance of the enzyme are significantly enhanced. The nCATs are covalently bound on cellulose acetate fibers to enable the enzyme sticking to the cigarette filters.The electron paramagnetic resonance (EPR) and Saltzman procedure reveal that the nCATs are able to efficiently scavenge 90% of the free radicals in tobacco smoke. The use of such nCATs with improved enzyme thermal stability opens up new opportunities for future application in cigarette filters. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27701]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lizhi,Yu, Wei,Luo, Dan,et al. Catalase Nanocapsules Protected by Polymer Shells for Scavenging Free Radicals of Tobacco Smoke[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(32):5159-5165. |
| APA | Liu, Lizhi.,Yu, Wei.,Luo, Dan.,Xue, Zhenjie.,Qin, Xiaoyun.,...&Wang, Tie.(2015).Catalase Nanocapsules Protected by Polymer Shells for Scavenging Free Radicals of Tobacco Smoke.ADVANCED FUNCTIONAL MATERIALS,25(32),5159-5165. |
| MLA | Liu, Lizhi,et al."Catalase Nanocapsules Protected by Polymer Shells for Scavenging Free Radicals of Tobacco Smoke".ADVANCED FUNCTIONAL MATERIALS 25.32(2015):5159-5165. |
入库方式： OAI收割
来源：化学研究所
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