DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives
文献类型：期刊论文
| 作者 | Liu, Ying1,2; Wang, Linlin1; Zhou, Jin1; Wu, Shangrong1; Wei, Yongbiao1; Chang, Ang1; Liu, Xiangjun1; Shangguan, Dihua1 |
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 121页码:328-335 |
| 关键词 | Quinacridone derivatives DNA G-quadruplexes Cell permeability Cellular localization Fluorescent probes |
| 英文摘要 | Quinacridone derivatives (QAs) are widely used in industrial colorant, chemical sensors and organic optoelectronic devices; however their biological applications are rarely reported. Here we describe the interaction of QAs with different DNA forms and cancer cells. Quinacridone and N,N'-bis(5-bromopentyl) quinacridone (QAB) selectively bind parallel G-quadruplex DNA through end-stacking. N,N'-bis(methylpiperazinylpentyl) quinacridone (QAP) and N,N'-bis(dimethyl-aminopentyl) quinacridone (QAT) strongly bind all DNA forms through hydrogen bonding and electrostatic interaction of the alkylamine side chains and DNA. Quinacridone does not enter living cells; QAB enters living cells and mainly locates in lysosome; QAP and QAT enter living cells and locate in whole cells, especially in nuclei through binding DNA. However, these QAs do not show significant cytotoxicity. These results suggest that side chains greatly affect the DNA interaction, cellular permeability and localization of QAs, and provide useful information for the design of DNA-binding drugs and fluorescent probes. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27716]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ying,Wang, Linlin,Zhou, Jin,et al. DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives[J]. DYES AND PIGMENTS,2015,121:328-335. |
| APA | Liu, Ying.,Wang, Linlin.,Zhou, Jin.,Wu, Shangrong.,Wei, Yongbiao.,...&Shangguan, Dihua.(2015).DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives.DYES AND PIGMENTS,121,328-335. |
| MLA | Liu, Ying,et al."DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives".DYES AND PIGMENTS 121(2015):328-335. |
入库方式： OAI收割
来源：化学研究所
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