Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging
文献类型：期刊论文
| 作者 | Wang, Ke1,2; Zhang, Xiaoyong1,2,3; Zhang, Xiqi1,2; Fan, Xingliang1,2; Huang, Zengfang1,2; Chen, Yi4; Wei, Yen1,2 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:32页码:5891-5898 |
| 英文摘要 | PEGylated red fluorescent nanoparticles with excellent biocompatibility and photostablity were facilely prepared from nonluminous materials: first red fluorescent nanoparticles (GCC NPs) were robustly prepared from chitosan and glutaraldehyde; then the amino groups and hydroxyl groups on the GCC NP surfaces were modified with 2-bromoisobutyryl bromide to obtain GCC-Br, which was employed as the nanoparticles' initiator in the ATRP system to finally obtain the GCC-poly(PEGMA) conjugates. The resulting GCC-poly(PEGMA) can emit a biofavorable deep red luminescence, which is quite stable and antiphotobleaching. Furthermore, GCC-poly(PEGMA) demonstrated excellent biocompatibility and water dispersibility due to the PEGMA chains conjugated on the surface; and the abundant hydroxyl groups on the surface can be further functionalized with diverse other groups or large biomolecules. This construction method demonstrated great advantages due to its simple strategy and economic value, and the NPs' successful cellular imaging endows them with a lot of potential for various biomedical applications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27780]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Tsinghua Univ, Minist Educ, Dept Chem, Beijing 100084, Peoples R China 2.Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China 3.Nanchang Univ, Inst Polymers, Dept Chem, Nanchang 330031, Peoples R China 4.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ke,Zhang, Xiaoyong,Zhang, Xiqi,et al. Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging[J]. POLYMER CHEMISTRY,2015,6(32):5891-5898. |
| APA | Wang, Ke.,Zhang, Xiaoyong.,Zhang, Xiqi.,Fan, Xingliang.,Huang, Zengfang.,...&Wei, Yen.(2015).Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging.POLYMER CHEMISTRY,6(32),5891-5898. |
| MLA | Wang, Ke,et al."Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging".POLYMER CHEMISTRY 6.32(2015):5891-5898. |
入库方式： OAI收割
来源：化学研究所
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