Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures
文献类型：期刊论文
| 作者 | Li, Juan1,2,3,4,5; Hong, Cheng-Yi1; Wu, Shu-Xian1; Liang, Hong1; Wang, Li-Ping1; Huang, Guoming1; Chen, Xian1; Yang, Huang-Hao1; Shangguan, Dihua2,3,6; Tan, Weihong2,3,4,5 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2015-09-09 |
| 卷号 | 137期号:35页码:11210-11213 |
| 英文摘要 | Hydrophobic nanoparticles have shown substantial potential for bioanalysis and biomedical applications. However, their use is hindered by complex phase transfer and inefficient surface modification. This paper reports a facile and universal strategy for phase transfer and surface biofunctionalization of hydrophobic nanomaterials using aptamer-pendant DNA tetrahedron nanostructures (Apt-tet). The Janus DNA tetrahedron nanostructures are constructed by three carboxyl group modified DNA strands and one aptamer sequence. The pendant linear sequence is an aptamer, in this case AS 1411, known to specifically bind nudeolin, typically overexpressed on the plasma membranes of tumor cells. The incorporation of the aptamers adds targeting ability and also enhances intracellular uptake. Phase-transfer efficiency using Apt-tet is much higher than that achieved using single-stranded DNA. In addition, the DNA tetrahedron nanostructures can be programmed to permit the incorporation of other functional nucleic acids, such as DNAzymes, siRNA, or antisense DNA, allowing, in turn, the construction of promising theranostic nanoagents for bioanalysis and biomedical applications. Given these unique features, we believe that our strategy of surface modification and functionalization may become a new paradigm in phase-transfer-agent design and further expand biomedical applications of hydrophobic nanomaterials. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28387]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Key Lab Anal & Detect Technol Food Safety,MOE & F, Fuzhou 350002, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemometr, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China 3.Hunan Univ, Coll Biol, Collaborat Innovat Ctr Mol Engn & Theranost, Changsha 410082, Hunan, Peoples R China 4.Univ Florida, UF Hlth Canc Ctr, Ctr Res Bionano Interface, Dept Chem, Gainesville, FL 32611 USA 5.Univ Florida, UF Hlth Canc Ctr, Ctr Res Bionano Interface, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA 6.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Juan,Hong, Cheng-Yi,Wu, Shu-Xian,et al. Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(35):11210-11213. |
| APA | Li, Juan.,Hong, Cheng-Yi.,Wu, Shu-Xian.,Liang, Hong.,Wang, Li-Ping.,...&Tan, Weihong.(2015).Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(35),11210-11213. |
| MLA | Li, Juan,et al."Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.35(2015):11210-11213. |
入库方式： OAI收割
来源：化学研究所
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