An Online Electrochemical System for Continuous Measurement of Glutamate with Signal Amplification by Enzymatic Substrate Cycling
文献类型：期刊论文
| 作者 | Zhang, Zipin1; Xiao, Tongfang1; Hao, Jie1; Yu, Ping1; Ohsaka, Takeo2; Mao, Lanqun1 |
| 刊名 | ELECTROANALYSIS
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 27期号:10页码:2406-2411 |
| 关键词 | OECS In vivo microdialysis Enzymatic substrate cycling Glutamate |
| 英文摘要 | This study demonstrates a new online electrochemical system (OECS) for continuous monitoring of glutamate by efficiently integrating in vivo microdialysis and selective electrochemical detection with an enhanced sensitivity through enzymatic substrate cycling. We find that the involvement of enzymatic substrate cycling in the biosensing scheme remarkably increases the sensitivity of the OECS toward the measurements of glutamate. Moreover, the OECS demonstrated here is stable, reproducible, and selective and could thus be potentially useful for continuous monitoring of glutamate release in central nervous system. This study essentially offers a new approach to the continuous measurements of cerebral glutamate release, which is believed to find interesting applications in understanding the molecular basis underlying brain functions. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28901]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Tokyo Inst Technol, Interdisciplinary Grad Sch Sci & Engn, Dept Elect Chem, Midori Ku, Yokohama, Kanagawa 2268502, Japan |
| 推荐引用方式 GB/T 7714 | Zhang, Zipin,Xiao, Tongfang,Hao, Jie,et al. An Online Electrochemical System for Continuous Measurement of Glutamate with Signal Amplification by Enzymatic Substrate Cycling[J]. ELECTROANALYSIS,2015,27(10):2406-2411. |
| APA | Zhang, Zipin,Xiao, Tongfang,Hao, Jie,Yu, Ping,Ohsaka, Takeo,&Mao, Lanqun.(2015).An Online Electrochemical System for Continuous Measurement of Glutamate with Signal Amplification by Enzymatic Substrate Cycling.ELECTROANALYSIS,27(10),2406-2411. |
| MLA | Zhang, Zipin,et al."An Online Electrochemical System for Continuous Measurement of Glutamate with Signal Amplification by Enzymatic Substrate Cycling".ELECTROANALYSIS 27.10(2015):2406-2411. |
入库方式： OAI收割
来源：化学研究所
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