Ratiometric Fluorescent Polymeric Thermometer for Thermogenesis Investigation in Living Cells
文献类型：期刊论文
| 作者 | Qiao, Juan1; Hwang, Yoon-Ho2; Chen, Chuan-Fang3; Qi, Li1; Dong, Ping4,5; Mu, Xiao-Yu1; Kim, Dong-Pyo2 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2015-10-20 |
| 卷号 | 87期号:20页码:10535-10541 |
| 英文摘要 | Intracellular temperature has a fundamental effect on cellular events. Herein, a novel fluorescent polymer ratiometric nanothermometer has been developed based on transferrin protein-stabilized gold nanoclusters as the targeting and fluorescent ratiometric unit and the thermosensitve polymer as the temperature sensing unit. The resultant nanothermometer could feature a high and spontaneous uptake into the HeLa cells and the ratiometric temperature sensing over the physiological temperature range. Moreover, the precise temperature sensing for intracellular heat generation in HeLa cells following calcium ions stress has been achieved. This practical intracellular thermometry could eliminate the interference of the intracellular surrounding environment in cancer cells without a microinjection procedure, which is user-friendly. The prepared new nanothermometer can provide tools for unveiling the intrinsic relationship between the intracellular temperature and ion channel function. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29165]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Pohang Univ Sci & Technol, Dept Chem Engn, Natl Creat Res Ctr Appl Microfluid Chem, Pohang 790784, Gyeongbuk, South Korea 3.Inst Elect Engn, Beijing Key Lab Bioelectromagnetism, Beijing 100190, Peoples R China 4.Chinese Acad Med Sci, Plast Surg Hosp, Res Ctr, Beijing 100730, Peoples R China 5.Peking Union Med Coll, Beijing 100730, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Juan,Hwang, Yoon-Ho,Chen, Chuan-Fang,et al. Ratiometric Fluorescent Polymeric Thermometer for Thermogenesis Investigation in Living Cells[J]. ANALYTICAL CHEMISTRY,2015,87(20):10535-10541. |
| APA | Qiao, Juan.,Hwang, Yoon-Ho.,Chen, Chuan-Fang.,Qi, Li.,Dong, Ping.,...&Kim, Dong-Pyo.(2015).Ratiometric Fluorescent Polymeric Thermometer for Thermogenesis Investigation in Living Cells.ANALYTICAL CHEMISTRY,87(20),10535-10541. |
| MLA | Qiao, Juan,et al."Ratiometric Fluorescent Polymeric Thermometer for Thermogenesis Investigation in Living Cells".ANALYTICAL CHEMISTRY 87.20(2015):10535-10541. |
入库方式： OAI收割
来源：化学研究所
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