Folic acid-conjugated fluorescent polymer for up-regulation folate receptor expression study via targeted imaging of tumor cells
文献类型：期刊论文
| 作者 | Qiao, Juan1; Dong, Ping2,3; Mu, Xiaoyu1,4; Qi, Li1; Xiao, Ran2,3 |
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2016-04-15 |
| 卷号 | 78页码:147-153 |
| 关键词 | Folate receptor expression Polymer-based fluorescent nano-conjugates Targeted imaging Up-regulation folate receptor |
| 英文摘要 | Thoroughly investigation of folate receptor (FR) expression related to targeting drug delivery in tumor cells has been intensively pursued in recent years. Herein, a simple and versatile strategy for determination of FR expression based on targeted imaging of tumor cells with fluorescent nano-conjugates was developed. The fluorescent nano-conjugates were composed of poly 2-vinyl-4,4-dimethyl azlactone (PVDMA) as the linker, folic acid as the targeting unit and amino-Rhodamine B as the fluorescent ligand. Owing to possessing dimethyl azlactone groups in polymer framework, PVDMA could easily reacted with amines or alcohols, and form water soluble materials. Fluorescent imaging studies indicated that the prepared nano-conjugates could specifically target tumor cells and monitor the over expressing of FR. Moreover, the FR expression up-regulation in HeLa cells through medicines regulation has been further explored. This new protocol opens an effective way through synthesis and design of novel fluorescent nano-conjugates for FR expression investigation in tumor cells via targeted imaging, showing great potential in drug delivery mechanism study and cancer therapy. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/30084]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Chinese Acad Med Sci, Res Ctr Plast Surg Hosp, Beijing 100144, Peoples R China 3.Peking Union Med Coll, Beijing 100144, Peoples R China 4.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Juan,Dong, Ping,Mu, Xiaoyu,et al. Folic acid-conjugated fluorescent polymer for up-regulation folate receptor expression study via targeted imaging of tumor cells[J]. BIOSENSORS & BIOELECTRONICS,2016,78:147-153. |
| APA | Qiao, Juan,Dong, Ping,Mu, Xiaoyu,Qi, Li,&Xiao, Ran.(2016).Folic acid-conjugated fluorescent polymer for up-regulation folate receptor expression study via targeted imaging of tumor cells.BIOSENSORS & BIOELECTRONICS,78,147-153. |
| MLA | Qiao, Juan,et al."Folic acid-conjugated fluorescent polymer for up-regulation folate receptor expression study via targeted imaging of tumor cells".BIOSENSORS & BIOELECTRONICS 78(2016):147-153. |
入库方式： OAI收割
来源：化学研究所
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