The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines
文献类型：期刊论文
| 作者 | Zhao, Zhenwen1; Cai, Qingchun2; Xu, Yan2 |
| 刊名 | LIPIDS
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 51期号:2页码:179-187 |
| 关键词 | Epithelial ovarian cancer (EOC) Lipidomic analyses Electrospray ionization-mass spectrometry (ESI-MS) ID8 Triacylglycerol (TAG) |
| 英文摘要 | Despite huge advances in the research of epithelial ovarian cancer (EOC), it remains the most lethal gynecological malignancy. Peritoneal tumor cell dissemination with cell survival and drug-resistance to taxane and platinum-based chemotherapy are two of the major challenges of EOC treatment. We have generated highly aggressive EOC cell lines (ID8-P1 lines or P1) from ID8-P0 (without in vivo passage, or P0) through in vivo passage in mice. We conducted lipidomic analyses in cells from ID8-P0 versus three ID8-P1 cell lines using ultra-high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry. A total of 16 classes of lipids (149 individual lipids) were analyzed and compared between P0 and P1 cells. In addition to overall lipid profiles in EOC cells, we had several novel observations. Several classes and species of lipids have been identified to be differentially present in P0 versus P1 cells, which are potentially involved in the acquired aggressiveness of P1 cells. Triacylglycerols (TAG) were dramatically increased under detachment stress in EOC cells. Since survival of EOC cells under detachment is one of the major obstacles for EOC treatment, further studies identifying the molecular mechanisms controlling TAG increase may lead to new treatment modalities for EOC. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/30123]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Indiana Univ Sch Med, Dept Obstet & Gynecol, 975 W Walnut St IB355A, Indianapolis, IN 46202 USA |
| 推荐引用方式 GB/T 7714 | Zhao, Zhenwen,Cai, Qingchun,Xu, Yan. The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines[J]. LIPIDS,2016,51(2):179-187. |
| APA | Zhao, Zhenwen,Cai, Qingchun,&Xu, Yan.(2016).The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines.LIPIDS,51(2),179-187. |
| MLA | Zhao, Zhenwen,et al."The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines".LIPIDS 51.2(2016):179-187. |
入库方式： OAI收割
来源：化学研究所
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