Enhanced Molecular Recognition between Nucleobases and Guanine-5 '-monophosphate-disodium (GMP) by Surfactant Aggregates in Aqueous Solution
文献类型：期刊论文
| 作者 | Liu, Zhang1; Wang, Dong2; Cao, Meiwen2; Han, Yuchun1; Xu, Hai2; Wang, Yilin1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2015-07-15 |
| 卷号 | 7期号:27页码:15078-15087 |
| 关键词 | Watson-Crick pairing oligomeric amphiphile self-assembling aggregate transition noncovalent bonds |
| 英文摘要 | Only specific base pairs on DNA can bind with each other through hydrogen bonds, which is called the Watson-Crick (W/C) pairing rule. However, without the constraint of DNA chains, the nucleobases in bulk aqueous solution usually do not follow the W/C pairing rule anymore because of the strong competitive effect of water and the multi-interaction edges of nucleobases. The present work applied surfactant aggregates noncovalently functionalized by nucleo-tide to enhance the recognition between nucleobases without DNA chains in aqueous solution, and it revealed the effects of their self-assembling ability and morphologies on the recognition. The cationic ammonium monomeric, dimeric, and trimeric surfactants DTAB, 12-3-12, and 12-3-12-3-12 were chosen. The surfactants with guanine-5'-monophosphate-disodium (GMP) form micelles, vesicles, and fingerprint-like and plate-like aggregates bearing the hydrogen-bonding sites Of GMP, respectively. The binding parameters of these aggregates with adenine (A), uracil (U), guanine (G), and cytosine(C) indicate that the surfactants can promote W/C recognitions in aqueous solution when they form vesicles (GMP/DTAB) or plate-like aggregates (GMP/12-3-12) with proper molecular packing compactness, which not only provide hydrophobic environments but also shield non-W/C recognition edges. However, the GMP/12-3-12 micelles with loose molecular packing; the GMP/12-3-12 fingerprint-like aggregates where the hydrogen bond sites of GMP are occupied by itself, and the GMP/12-3-12-3-12 vesicles with too strong self-assembling ability cannot promote W/C recognition. This work provides insight into how to design self-assemblies with the performance of enhanced molecule recognition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27880]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China 2.China Univ Petr East China, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhang,Wang, Dong,Cao, Meiwen,et al. Enhanced Molecular Recognition between Nucleobases and Guanine-5 '-monophosphate-disodium (GMP) by Surfactant Aggregates in Aqueous Solution[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(27):15078-15087. |
| APA | Liu, Zhang,Wang, Dong,Cao, Meiwen,Han, Yuchun,Xu, Hai,&Wang, Yilin.(2015).Enhanced Molecular Recognition between Nucleobases and Guanine-5 '-monophosphate-disodium (GMP) by Surfactant Aggregates in Aqueous Solution.ACS APPLIED MATERIALS & INTERFACES,7(27),15078-15087. |
| MLA | Liu, Zhang,et al."Enhanced Molecular Recognition between Nucleobases and Guanine-5 '-monophosphate-disodium (GMP) by Surfactant Aggregates in Aqueous Solution".ACS APPLIED MATERIALS & INTERFACES 7.27(2015):15078-15087. |
入库方式： OAI收割
来源：化学研究所
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