Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors
文献类型：期刊论文
| 作者 | Ding, Ke1,3; Zeng, Jianfeng2,3; Jing, Lihong1; Qiao, Ruirui1,3; Liu, Chunyan1; Jiao, Mingxia1; Li, Zhen2,3; Gao, Mingyuan1,3 |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:25页码:11075-11081 |
| 英文摘要 | By integrating high imaging sensitivity and high resolution in a single modality, photoacoustic (PA) imaging emerges as a promising diagnostic tool for clinical applications. Benefiting from the absorption in the near-infrared region (NIR), copper sulfide nanoparticles (NPs) as a contrast agent are potentially useful for increasing the sensitivity of PA imaging. However, the aqueous synthesis of size-tunable, biocompatible and colloidally stable copper sulfide NPs remains challenging due to the intrinsic dipole-dipole interactions among particles. In this work, aqueous synthesis of PEGylated copper sulfide NPs with controllable size between 3 and 7 nm was developed. The particle size-dependent contrast enhancement effect of the copper sulfide NPs for PA imaging was carefully studied both in vitro and in vivo. Although the contrast enhancement effect of the copper sulfide NPs is proportional to particle size, the in vivo studies revealed that copper sulfide NPs smaller than 5 nm presented higher tumor imaging performance, especially at the tumor boundary site, which was further discussed in combination with the pharmacokinetic behaviors of differently sized particles. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27987]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Soochow Univ, Coll Med, Sch Radiat Med & Protect, Suzhou 215123, Peoples R China 3.Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Suzhou 215123, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Ke,Zeng, Jianfeng,Jing, Lihong,et al. Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors[J]. NANOSCALE,2015,7(25):11075-11081. |
| APA | Ding, Ke.,Zeng, Jianfeng.,Jing, Lihong.,Qiao, Ruirui.,Liu, Chunyan.,...&Gao, Mingyuan.(2015).Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors.NANOSCALE,7(25),11075-11081. |
| MLA | Ding, Ke,et al."Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors".NANOSCALE 7.25(2015):11075-11081. |
入库方式： OAI收割
来源：化学研究所
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