Effect of composite SiO2@AuNPs on wound healing: In vitro and vivo studies
文献类型：期刊论文
| 作者 | Li, Xiaoqin1; Wang, Haifei1; Rong, Huilin1; Li, Wanhua2; Luo, Yuan2; Tian, Kai2; Quan, Dongqin2; Wang, Yongan2; Jiang, Long1 |
| 刊名 | JOURNAL OF COLLOID AND INTERFACE SCIENCE
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 445页码:312-319 |
| 关键词 | SiO2@AuNPs Cell proliferation NIH/3T3 cells Wound healing |
| 英文摘要 | Recently gold nanomaterials have been widely applied in the biomedical field, but their biosafety is still controversial. We immobilized small gold nanoparticles (AuNPs) on a large silica substrate to form silica-gold core-shell materials (SiO2@AuNPs) via classical seed-mediated growth. In vitro, 500 nm-SiO2@AuNPs could promote the proliferation of mouse embryonic fibroblast cells (NIH/3T3). The results of transmission electron microscope (TEM) showed that the vast majority of particles did not enter cells and that the morphology of microtubules experienced no change as observed in the confocal microscope images. The mechanism may be that the large silica substrate kept AuNPs outside the cells and the nanosize concavo-convex gold shell facilitated to cell adhesion, resulting in the proliferation. In vivo, a cutaneous full-thickness excisional wound rat model was applied to assess the healing efficiency of 500 nm-SiO2@AuNPs. The results indicated that SiO2@AuNPs could promote wound healing, which was potentially related to the anti-inflammatory and antioxidation of AuNPs. The pathological finding showed that the healing levels of SiO2@AuNPs were significantly better than those of the control groups. Our study may provide insight into the application of silica-gold core-shell materials in the treatment of cutaneous wounds. (C) 2015 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28210]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Colloids & Interface Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaoqin,Wang, Haifei,Rong, Huilin,et al. Effect of composite SiO2@AuNPs on wound healing: In vitro and vivo studies[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2015,445:312-319. |
| APA | Li, Xiaoqin.,Wang, Haifei.,Rong, Huilin.,Li, Wanhua.,Luo, Yuan.,...&Jiang, Long.(2015).Effect of composite SiO2@AuNPs on wound healing: In vitro and vivo studies.JOURNAL OF COLLOID AND INTERFACE SCIENCE,445,312-319. |
| MLA | Li, Xiaoqin,et al."Effect of composite SiO2@AuNPs on wound healing: In vitro and vivo studies".JOURNAL OF COLLOID AND INTERFACE SCIENCE 445(2015):312-319. |
入库方式： OAI收割
来源：化学研究所
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