Hierarchical Self-Assembly of Discrete Organoplatinum(II) Metallacycles with Polysaccharide via Electrostatic Interactions and Their Application for Heparin Detection
文献类型：期刊论文
| 作者 | Chen, Li-Jun1; Ren, Yuan-Yuan1; Wu, Nai-Wei1; Sun, Bin1,2,3; Ma, Jian-Qiu5; Zhang, Li4; Tan, Hongwei5; Liu, Minghua4; Li, Xiaopeng2,3; Yang, Hai-Bo1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2015-09-16 |
| 卷号 | 137期号:36页码:11725-11735 |
| 英文摘要 | In recent past years, investigation of hierarchical self-assembly for constructing artificial functional materials has attracted considerable attention. Discrete metallacydes based on coordination bonds have proven to be valid scaffolds to fabricate various supra-molecular polymers or smart soft matter through hierarchical self-assembly. Here, we present the first example of the hierarchical self-assembly of discrete metallacydes by taking advantage of the positive charges of the organoplatinum(II) metallacyde skeleton through multiple electrostatic interactions. Heparin, a sulfated glycosaminoglycan polymer that has been widely used as an anticoagulant drug, was selected to induce hierarchical self-assembly because of the existence of multiple negative charges. To investigate the hierarchical self-assembly process, an aggregation-induced emission (AIE) active moiety, tetra-phenylethylene (TPE), was introduced onto the metallacyde via coordination-driven self-assembly. Photophysical studies revealed that the addition of heparin to the tris-TPE metallacydes solution resulted in dramatic fluorescence enhancement, which supported the aggregation between metallacycle and heparin driven by multiple electrostatic interactions. Moreover, the entangled pearl-necklace networks were obtained through hierarchical self-assembly as detected by SEM, TEM, and LSCM experiments. In particular, single bead-like chains were observed in the AFM and TEM images, which provided direct, visual evidence for the aggregation of positively charged metallacydes and negatively charged heparin. More interestingly, further optical study demonstrated that this TPE-decorated metallacyde could function as a turn-on fluorescent probe for heparin detection with high sensitivity and selectivity. Thus, this research presents the first example of counter polyanion-induced hierarchical self-assembly of discrete metallacydes and provides a "proof-of-principle" method for heparin sensing and binding. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28404]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China 2.Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA 3.Texas State Univ, Mat Sci Engn & Commercializat Program, San Marcos, TX 78666 USA 4.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing 100080, Peoples R China 5.Beijing Normal Univ, Dept Chem, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Li-Jun,Ren, Yuan-Yuan,Wu, Nai-Wei,et al. Hierarchical Self-Assembly of Discrete Organoplatinum(II) Metallacycles with Polysaccharide via Electrostatic Interactions and Their Application for Heparin Detection[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(36):11725-11735. |
| APA | Chen, Li-Jun.,Ren, Yuan-Yuan.,Wu, Nai-Wei.,Sun, Bin.,Ma, Jian-Qiu.,...&Yang, Hai-Bo.(2015).Hierarchical Self-Assembly of Discrete Organoplatinum(II) Metallacycles with Polysaccharide via Electrostatic Interactions and Their Application for Heparin Detection.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(36),11725-11735. |
| MLA | Chen, Li-Jun,et al."Hierarchical Self-Assembly of Discrete Organoplatinum(II) Metallacycles with Polysaccharide via Electrostatic Interactions and Their Application for Heparin Detection".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.36(2015):11725-11735. |
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来源：化学研究所
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