Protease-Activated Ratio metric Fluorescent Probe for pH Mapping of Malignant Tumors
文献类型：期刊论文
| 作者 | Hou, Yi1; Zhou, Jin1; Gao, Zhenyu1,2; Sun, Xiaoyu1; Liu, Chunyan1; Shangguan, Dihua1; Yang, Wensheng2; Gao, Mingyuan1 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 9期号:3页码:3199-3205 |
| 关键词 | Fe3O4 nanocrystals protease-activated pH mapping ratiometric fluorescence smart probe |
| 英文摘要 | A protease-activated ratiometric fluorescent probe based on fluorescence resonance energy transfer between a pH-sensitive fluorescent dye and biocompatible Fe3O4 nanocrystals was constructed. A peptide substrate of MMP-9 served as a linker between the particle quencher and the chromophore that was covalently attached to the antitumor antibody. The optical response of the probe to activated MMP-9 and gastric cell line SGC7901 tumor cells was investigated, followed by in vivo tumor imaging. Based on the ratiometric pH response to the tumor microenvironment, the resulting probe was successfully used to image the pH of subcutaneous tumor xenografts. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28479]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Jilin Univ, Coll Chem, Changchun 130012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Yi,Zhou, Jin,Gao, Zhenyu,et al. Protease-Activated Ratio metric Fluorescent Probe for pH Mapping of Malignant Tumors[J]. ACS NANO,2015,9(3):3199-3205. |
| APA | Hou, Yi.,Zhou, Jin.,Gao, Zhenyu.,Sun, Xiaoyu.,Liu, Chunyan.,...&Gao, Mingyuan.(2015).Protease-Activated Ratio metric Fluorescent Probe for pH Mapping of Malignant Tumors.ACS NANO,9(3),3199-3205. |
| MLA | Hou, Yi,et al."Protease-Activated Ratio metric Fluorescent Probe for pH Mapping of Malignant Tumors".ACS NANO 9.3(2015):3199-3205. |
入库方式： OAI收割
来源：化学研究所
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