Near-Infrared-Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy
文献类型：期刊论文
| 作者 | Shao, Jingxin1; Xuan, Mingjun1; Dai, Luru2; Si, Tieyan1; Li, Junbai3; He, Qiang1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015-10-19 |
| 卷号 | 54期号:43页码:12782-12787 |
| 关键词 | gold nanorods layer-by-layer microcapsules photothermal therapy vapor bubbles |
| 英文摘要 | Photothermal therapy based on gold nanostructures has been widely investigated as a state-of-the-art noninvasive therapy approach. Because single nanoparticles cannot harvest sufficient energy, self-assemblies of small plasmonic particles into large aggregates are required for enhanced photothermal performance. Self-assembled gold nanorods in lipid bilayer-modified microcapsules are shown to localize at tumor sites, generate vapor bubbles under near-infrared light exposure, and subsequently damage tumor tissues. The polyelectrolyte multilayer enables dense packing of gold nanorods during the assembly process, which leads to the formation of vapor bubbles around the excited capsules. The resulting vapor bubbles achieve a high efficiency of suppressing tumor growth compared to single gold nanorods. In vivo experiments demonstrated the ability of soft-polymer multilayer microcapsules to cross the biological barriers of the body and localize at target tissues. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29119]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Harbin Inst Technol, Micro Nanotechnol Res Ctr, Key Lab Microsyst & Microstruct Mfg, Harbin 150080, Peoples R China 2.Natl Ctr Nanosci & Technol, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Jingxin,Xuan, Mingjun,Dai, Luru,et al. Near-Infrared-Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(43):12782-12787. |
| APA | Shao, Jingxin,Xuan, Mingjun,Dai, Luru,Si, Tieyan,Li, Junbai,&He, Qiang.(2015).Near-Infrared-Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(43),12782-12787. |
| MLA | Shao, Jingxin,et al."Near-Infrared-Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.43(2015):12782-12787. |
入库方式： OAI收割
来源：化学研究所
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