Chemical Spacer Design for Engineering the Relaxometric Properties of Core-Shell Structured Rare Earth Nanoparticles
文献类型：期刊论文
| 作者 | Huang, Jiayi; Hou, Yi; Liu, Chunyan; Jing, Lihong; Ma, Tiancong; Sun, Xiaodan; Gao, Mingyuan |
| 刊名 | CHEMISTRY OF MATERIALS
 |
| 出版日期 | 2015-12-08 |
| 卷号 | 27期号:23页码:7918-7925 |
| 英文摘要 | The development of T-1/T-2 dual-modality contrast agents for magnetic resonance imaging (MRI) is beneficial for eliminating artifacts. However, T-1 and T-2 agents in the case of direct contact will interfere with each other, and the intrinsic mechanism remains unclear yet. Gadolinium(III) is widely used as T-1 contrast agents, while dysprosium(III) exhibits the strongest magnetic moment among rare earth (RE) elements due to the spin-orbital coupling and can potentially be used as T-2 contrast agents. The very similar chemical properties of RE elements allow integration of Gd(III) and Dy(III) within single nanocrystals for investigating the interactions between T-1, and T2 components so as to achieve T-1/T-2 dual-modality contrast agents with optimized performance. Therefore, core-shell-shell structured NaDyF4@NaREF4@NaGdF4:Yb, Er nanocrystals were prepared via a seed-mediated growth approach and Gd(III), Er(III), and Y(III) were chosen to construct NaREF4 spacer layer for mediating the interactions between Dy(III) and Gd(III) ions. It was found out that, with the decrease of the electron cloud distortion ability from Gd(III) to Y(III), the PEGylated core-shell-shell particles present increasing longitudinal relarivity values from 0.50 to 1.82 mM(-1) s(-1). On the basis of the longitudinal relaxivity theory and polarizability of different RE elements, the above tendency can be interpreted by the distortion tendency of the electron cloud of RE(III) in the spacer layer which strongly mediates the interactions between electron clouds of Dy(III) and Gd(III) ions. Further upconversion luminescence spectroscopy study in combination with the relaxivity measurements on nanocrystals with thicker spacer (3.5 vs 1.9 nm) also supported the above explanation. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29409]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Jiayi,Hou, Yi,Liu, Chunyan,et al. Chemical Spacer Design for Engineering the Relaxometric Properties of Core-Shell Structured Rare Earth Nanoparticles[J]. CHEMISTRY OF MATERIALS,2015,27(23):7918-7925. |
| APA | Huang, Jiayi.,Hou, Yi.,Liu, Chunyan.,Jing, Lihong.,Ma, Tiancong.,...&Gao, Mingyuan.(2015).Chemical Spacer Design for Engineering the Relaxometric Properties of Core-Shell Structured Rare Earth Nanoparticles.CHEMISTRY OF MATERIALS,27(23),7918-7925. |
| MLA | Huang, Jiayi,et al."Chemical Spacer Design for Engineering the Relaxometric Properties of Core-Shell Structured Rare Earth Nanoparticles".CHEMISTRY OF MATERIALS 27.23(2015):7918-7925. |
入库方式： OAI收割
来源：化学研究所
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