Antibacterial Activity of Geminized Amphiphilic Cationic Homopolymers
文献类型：期刊论文
| 作者 | Wang, Hui1; Shi, Xuefeng1; Yu, Danfeng1; Zhang, Jian2,3; Yang, Guang2,3; Cui, Yingxian2,3; Sun, Keji4; Wang, Jinben1; Yan, Haike1 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2015-12-22 |
| 卷号 | 31期号:50页码:13469-13477 |
| 英文摘要 | The current study is aimed at investigating the effect of cationic charge density and hydrophobicity on the antibacterial and hemolytic activities. Two kinds of cationic surfmers, containing single or double hydrophobic tails (octyl chains or benzyl groups), and the corresponding homopolymers were synthesized. The antimicrobial activity of these candidate antibacterials was studied by microbial growth inhibition assays against Escherichia coli, and hemolysis activity was carried out using human red blood cells. It was interestingly found that the homopolymers were much more effective in antibacterial property than their corresponding monomers. Furthermore, the geminized homopolymers had significantly higher antibacterial activity than that of their counterparts but with single amphiphilic side chains in each repeated unit. Geminized homopolymers, with high positive charge density and moderate hydrophobicity (such as benzyl groups), combine both advantages of efficient antibacterial property and prominently high selectivity. To further explain the antibacterial performance of the novel polymer series, the molecular interaction mechanism is proposed according to experimental data which shows that these specimens are likely to kill microbes by disrupting bacterial membranes, leading them unlikely to induce resistance. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29578]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 2.State Key Lab Offshore Oil Exploitat, Beijing 100027, Peoples R China 3.CNOOC Res Inst, Beijing 100027, Peoples R China 4.SINOPEC, Shengli Oilfield Branch Co, Oil Prod Technol Res Inst, Dongying 257000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Shi, Xuefeng,Yu, Danfeng,et al. Antibacterial Activity of Geminized Amphiphilic Cationic Homopolymers[J]. LANGMUIR,2015,31(50):13469-13477. |
| APA | Wang, Hui.,Shi, Xuefeng.,Yu, Danfeng.,Zhang, Jian.,Yang, Guang.,...&Yan, Haike.(2015).Antibacterial Activity of Geminized Amphiphilic Cationic Homopolymers.LANGMUIR,31(50),13469-13477. |
| MLA | Wang, Hui,et al."Antibacterial Activity of Geminized Amphiphilic Cationic Homopolymers".LANGMUIR 31.50(2015):13469-13477. |
入库方式： OAI收割
来源：化学研究所
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