Supramolecular synergy in the boundary lubrication of synovial joints
文献类型：期刊论文
| 作者 | Seror, Jasmine1; Zhu, Linyi1,2; Goldberg, Ronit1; Day, Anthony J.3; Klein, Jacob1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 6 |
| 英文摘要 | Hyaluronan, lubricin and phospholipids, molecules ubiquitous in synovial joints, such as hips and knees, have separately been invoked as the lubricants responsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot explain the extremely low friction at the high pressures of such joints. We find that surface-anchored hyaluronan molecules complex synergistically with phosphatidylcholine lipids present in joints to form a boundary lubricating layer, which, with coefficient of friction mu approximate to 0.001 at pressures to over 100 atm, has a frictional behaviour resembling that of articular cartilage in the major joints. Our findings point to a scenario where each of the molecules has a different role but must act together with the others: hyaluronan, anchored at the outer surface of articular cartilage by lubricin molecules, complexes with joint phosphatidylcholines to provide the extreme lubrication of synovial joints via the hydration-lubrication mechanism. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28532]  |
| 专题 | 化学研究所_其它 |
| 作者单位 | 1.Weizmann Inst Sci, Dept Mat & Interfaces, IL-76100 Rehovot, Israel 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England |
| 推荐引用方式 GB/T 7714 | Seror, Jasmine,Zhu, Linyi,Goldberg, Ronit,et al. Supramolecular synergy in the boundary lubrication of synovial joints[J]. NATURE COMMUNICATIONS,2015,6. |
| APA | Seror, Jasmine,Zhu, Linyi,Goldberg, Ronit,Day, Anthony J.,&Klein, Jacob.(2015).Supramolecular synergy in the boundary lubrication of synovial joints.NATURE COMMUNICATIONS,6. |
| MLA | Seror, Jasmine,et al."Supramolecular synergy in the boundary lubrication of synovial joints".NATURE COMMUNICATIONS 6(2015). |
入库方式： OAI收割
来源：化学研究所
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