Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo
文献类型：期刊论文
| 作者 | Zhang, Jinfeng1,2; Liang, Yu-Chuan8; Lin, Xudong3; Zhu, Xiaoyue1,2; Yan, Li1,2; Li, Shengliang7; Yang, Xia1,2; Zhu, Guangyu5; Rogach, Andrey L.2; Yu, Peter K. N.2,4 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 9期号:10页码:9741-9756 |
| 关键词 | self-monitoring self-delivery FRET combination therapy in vitro in vivo |
| 英文摘要 | Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. Herein, a self-monitored and self-delivered photosensitizer-doped FRET nanoparticle (NP) drug delivery system (DDS) is designed for this purpose. During preparation, a donor/acceptor pair of perylene and 5,10,15,20-tetro (4-pyridyl) porphyrin (H2TPyP) is co-doped into a chemotherapeutic anticancer drug curcumin (Cur) matrix. In the system, Cur works as a chemotherapeutic agent. In the meantime, the green fluorescence of Cur molecules is quenched (OFF) in the form of NPs and can be subsequently recovered (ON) upon release in tumor cells, which enables additional imaging and real-time self-monitoring capabilities. H2TPyP is employed as a photodynamic therapeutic drug, but it also emits efficient NIR fluorescence for diagnosis via FRET from perylene. By exploiting the emission characteristics of these two emitters, the combinatorial drugs provide a real-time dual-fluorescent imaging/tracking system in vitro and in vivo, and this has not been reported before in self-delivered DDS which simultaneously shows a high drug loading capacity (77.6%cur). Overall, our carrier-free DDS is able to achieve chemotherapy (Cur), photodynamic therapy (H2TPyP), and real-time self-monitoring of the release and distribution of the nanomedicine (Cur and H2TPyP). More importantly, the as-prepared NPs show high cancer therapeutic efficiency both in vitro and in vivo. We expect that the present real-time self-monitored and self-delivered DDS with multiple-therapeutic and multiple-fluorescent ability will have broad applications in future cancer therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29209]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | 1.City Univ Hong Kong, COSDAF, Kowloon 999077, Hong Kong, Peoples R China 2.City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon 999077, Hong Kong, Peoples R China 3.City Univ Hong Kong, Dept Mech & Biomed Engn, Kowloon 999077, Hong Kong, Peoples R China 4.City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon 999077, Hong Kong, Peoples R China 5.City Univ Hong Kong, Dept Biol & Chem, Kowloon 999077, Hong Kong, Peoples R China 6.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China 7.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 8.Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan 9.Mackay Mem Hosp, Dept Plast Surg, Taipei 10449, Taiwan 10.Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan |
| 推荐引用方式 GB/T 7714 | Zhang, Jinfeng,Liang, Yu-Chuan,Lin, Xudong,et al. Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo[J]. ACS NANO,2015,9(10):9741-9756. |
| APA | Zhang, Jinfeng.,Liang, Yu-Chuan.,Lin, Xudong.,Zhu, Xiaoyue.,Yan, Li.,...&Lee, Chun-Sing.(2015).Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo.ACS NANO,9(10),9741-9756. |
| MLA | Zhang, Jinfeng,et al."Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo".ACS NANO 9.10(2015):9741-9756. |
入库方式： OAI收割
来源：化学研究所
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