A Supramolecular Antibiotic Switch for Antibacterial Regulation
文献类型：期刊论文
| 作者 | Bai, Haotian; Yuan, Huanxiang; Nie, Chenyao; Wang, Bing; Lv, Fengting; Liu, Libing; Wang, Shu |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015-11-02 |
| 卷号 | 54期号:45页码:13208-13213 |
| 关键词 | antibacterial regulation antibiotics bacterial resistance supramolecular assembly molecular switches |
| 英文摘要 | A supramolecular antibiotic switch is described that can reversibly turn-on and turn-off its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29188]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Haotian,Yuan, Huanxiang,Nie, Chenyao,et al. A Supramolecular Antibiotic Switch for Antibacterial Regulation[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(45):13208-13213. |
| APA | Bai, Haotian.,Yuan, Huanxiang.,Nie, Chenyao.,Wang, Bing.,Lv, Fengting.,...&Wang, Shu.(2015).A Supramolecular Antibiotic Switch for Antibacterial Regulation.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(45),13208-13213. |
| MLA | Bai, Haotian,et al."A Supramolecular Antibiotic Switch for Antibacterial Regulation".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.45(2015):13208-13213. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。