中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A Supramolecular Antibiotic Switch for Antibacterial Regulation

文献类型:期刊论文

作者Bai, Haotian; Yuan, Huanxiang; Nie, Chenyao; Wang, Bing; Lv, Fengting; Liu, Libing; Wang, Shu
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2015-11-02
卷号54期号:45页码:13208-13213
关键词antibacterial regulation antibiotics bacterial resistance supramolecular assembly molecular switches
英文摘要A supramolecular antibiotic switch is described that can reversibly turn-on and turn-off its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view.
收录类别SCI
语种英语
公开日期2016-05-09
源URL[http://ir.iccas.ac.cn/handle/121111/29188]  
专题化学研究所_有机固体实验室
作者单位Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Bai, Haotian,Yuan, Huanxiang,Nie, Chenyao,et al. A Supramolecular Antibiotic Switch for Antibacterial Regulation[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(45):13208-13213.
APA Bai, Haotian.,Yuan, Huanxiang.,Nie, Chenyao.,Wang, Bing.,Lv, Fengting.,...&Wang, Shu.(2015).A Supramolecular Antibiotic Switch for Antibacterial Regulation.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(45),13208-13213.
MLA Bai, Haotian,et al."A Supramolecular Antibiotic Switch for Antibacterial Regulation".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.45(2015):13208-13213.

入库方式: OAI收割

来源:化学研究所

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