Novel colorimetric and fluorescent off-on enantiomers with high selectivity for Fe3+ imaging in living cells
文献类型：期刊论文
| 作者 | Fan, Chunhua1; Huang, Ximing1; Han, Liheng2; Lu, Zhengliang1; Wang, Zhuo3; Yi, Yuanping2 |
| 刊名 | SENSORS AND ACTUATORS B-CHEMICAL
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 224页码:592-599 |
| 关键词 | Chirality Fluorescent chemosensor Iron Living cell |
| 英文摘要 | Two novel colorimetric and fluorescent off-on enantiomers (R/S-RBOL) were developed to detect Fe3' in aqueous and biological samples through probing the integrated changes in fluorescence, circular dichroism (CD) and circularly polarized luminescence (CPL). The fluorescence intensity of R/S-RBOL is linearly proportional to the Fe3+ concentration in the range of 0-20 equiv., bringing out a detection limit of 1.83 x 10(-7)M. The Job's plot indicates a 1:1 binding stoichiometry of RBOL:Fe3+, which is further confirmed by ESI-MS analysis. Moreover, the RBOLs exhibit a dual-readout response in colour and fluorescence, rendering them suitable to sense Fe3+ in living cells with low cytotoxicity. In order to shed some light on the detection mechanism, the coordination between R/S-RBOL and Fe3+ is unravelled by DFT calculations. From the free RBOL to the RBOL-Fe3+ complex, the spiro-lactam ring is opened to interact with Fe3+ via the lactam N and O, imine N and hydroxyl 0 atoms in the form of a ferric six-coordinate structure. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29744]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | 1.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Beijing Univ Chem Technol, Fac Sci, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Chunhua,Huang, Ximing,Han, Liheng,et al. Novel colorimetric and fluorescent off-on enantiomers with high selectivity for Fe3+ imaging in living cells[J]. SENSORS AND ACTUATORS B-CHEMICAL,2016,224:592-599. |
| APA | Fan, Chunhua,Huang, Ximing,Han, Liheng,Lu, Zhengliang,Wang, Zhuo,&Yi, Yuanping.(2016).Novel colorimetric and fluorescent off-on enantiomers with high selectivity for Fe3+ imaging in living cells.SENSORS AND ACTUATORS B-CHEMICAL,224,592-599. |
| MLA | Fan, Chunhua,et al."Novel colorimetric and fluorescent off-on enantiomers with high selectivity for Fe3+ imaging in living cells".SENSORS AND ACTUATORS B-CHEMICAL 224(2016):592-599. |
入库方式： OAI收割
来源：化学研究所
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