Preparation of Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing
文献类型：期刊论文
| 作者 | Li, Meng; Li, Shengliang; Chen, Hui; Hu, Rong; Liu, Libing; Lv, Fengting; Wang, Shu |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016-01-13 |
| 卷号 | 8期号:1页码:42-46 |
| 关键词 | conjugated polymer prodrug cell imaging tumor cell killing nitrogen mustard |
| 英文摘要 | In this work, a new conjugated polymer poly(fluorene-co-phenylene) derivative containing pendent quaternized chlormethine (PFP-Chl) was synthesized by covalent linking small molecular prodrug groups onto conjugated polymer side chains. H2O2-sensitive prodrug with an eight-member-cyclic boronate ester structure could suffer from H2O2-triggered nitrogen mustard release and further DNA cross-linking and alkylation. PFP-Chl combines therapeutic characteristic with excellent optical property of conjugated polymers. It is found that PFP-Chl could enter into cells by endocytosis to simultaneously exhibit abilities of fluorescent imaging and tumor cell inhibition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/30103]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meng,Li, Shengliang,Chen, Hui,et al. Preparation of Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(1):42-46. |
| APA | Li, Meng.,Li, Shengliang.,Chen, Hui.,Hu, Rong.,Liu, Libing.,...&Wang, Shu.(2016).Preparation of Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing.ACS APPLIED MATERIALS & INTERFACES,8(1),42-46. |
| MLA | Li, Meng,et al."Preparation of Conjugated Polymer Grafted with H2O2-Sensitive Prodrug for Cell Imaging and Tumor Cell Killing".ACS APPLIED MATERIALS & INTERFACES 8.1(2016):42-46. |
入库方式： OAI收割
来源：化学研究所
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