Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression
文献类型：期刊论文
| 作者 | Xu,Weiguo; Ding; Li,Lingyu; Xiao,Chunsheng; Zhuang,Xiuli; Chen,Xuesi |
| 刊名 | chemical communications
 |
| 出版日期 | 2015 |
| 卷号 | 51期号:31页码:6812-6815 |
| 关键词 | CANCER INHIBITOR |
| 通讯作者 | ding,jx |
| 英文摘要 | an acid-labile dextran-bortezomib conjugate (dex-btz), i.e., a macro-molecularized proteasome inhibitor, is synthesized by a boron esterification reaction. the prodrug exhibits intracellular acidity-accelerated btz release, and up-regulated inhibition efficacies toward hypoxic tumor in vitro and in vivo through both nf-kappa b- and ers-mediated apoptosis signaling pathways. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64715]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu,Weiguo,Ding,Li,Lingyu,et al. Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression[J]. chemical communications,2015,51(31):6812-6815. |
| APA | Xu,Weiguo,Ding,Li,Lingyu,Xiao,Chunsheng,Zhuang,Xiuli,&Chen,Xuesi.(2015).Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression.chemical communications,51(31),6812-6815. |
| MLA | Xu,Weiguo,et al."Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression".chemical communications 51.31(2015):6812-6815. |
入库方式： OAI收割
来源：长春应用化学研究所
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