Development of the Affinity Materials for Phosphorylated Proteins/Peptides Enrichment in Phosphoproteomics Analysis
文献类型：期刊论文
| 作者 | Wang,Zhi-Gang; Lv,Nan; Bi,Wen-Zhi; Zhang,Ji-Lin; Ni,Jia-Zuan |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:16页码:8377-8392 |
| 关键词 | HIGHLY SELECTIVE ENRICHMENT MASS-SPECTROMETRIC ANALYSIS CORE-SHELL MICROSPHERES MALDI-TOF-MS FUNCTIONALIZED MAGNETIC NANOPARTICLES MODIFIED SILICA NANOPARTICLES ALPHA-ZIRCONIUM PHOSPHATE TIO2 NANOCRYSTAL CLUSTERS METAL-ORGANIC FRAMEWORK PHOSPHOPEPTIDE ENRICHMENT |
| 通讯作者 | zhang,jl |
| 英文摘要 | reversible protein phosphorylation is a key event in numerous biological processes. mass spectrometry (ms) is the most powerful analysis tool in modern phosphoproteomics. however, the direct ms analysis of phosphorylated proteins/peptides is still a big challenge because of the low abundance and insufficient ionization of phosphorylated proteins/peptides as well as the suppression effects of nontargets. enrichment of phosphorylated proteins/peptides by affinity material's from complex biosamples is the most widely used strategy to enhance the ms detection. the demand of efficiently enriching phosphorylated proteins/peptides has spawned diverse affinity materials based on different enrichment principles (e.g., electronic attraction, chelating). in this review, we summarize the recent development of various affinity materials for phosphorylated proteins] peptides enrichment. we will highlight the design and fabrication of these affinity materials, discuss the enrichment mechanisms involved in different affinity materials, and suggest the future challenges and research directions in this field. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64744]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang,Zhi-Gang,Lv,Nan,Bi,Wen-Zhi,et al. Development of the Affinity Materials for Phosphorylated Proteins/Peptides Enrichment in Phosphoproteomics Analysis[J]. acs applied materials & interfaces,2015,7(16):8377-8392. |
| APA | Wang,Zhi-Gang,Lv,Nan,Bi,Wen-Zhi,Zhang,Ji-Lin,&Ni,Jia-Zuan.(2015).Development of the Affinity Materials for Phosphorylated Proteins/Peptides Enrichment in Phosphoproteomics Analysis.acs applied materials & interfaces,7(16),8377-8392. |
| MLA | Wang,Zhi-Gang,et al."Development of the Affinity Materials for Phosphorylated Proteins/Peptides Enrichment in Phosphoproteomics Analysis".acs applied materials & interfaces 7.16(2015):8377-8392. |
入库方式： OAI收割
来源：长春应用化学研究所
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