pH-Responsive Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest Interaction
文献类型：期刊论文
| 作者 | Zhang,Zhe; Lv,Qiang; Gao,Xiaoye; Chen,Li; Cao,Yue; Yu,Shuangjiang; He,Chaoliang; Chen,Xuesi |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:16页码:8404-8411 |
| 关键词 | ANTICANCER DRUG-DELIVERY BLOCK-COPOLYMER MICELLES GENE DELIVERY POLYMERIC NANOPARTICLES INTRACELLULAR DRUG CYCLODEXTRIN DESIGN TUMOR BENZIMIDAZOLE CHEMOTHERAPY |
| 通讯作者 | chen,l |
| 英文摘要 | ph-responsive supramolecular amphiphilic micelles based on benzimidazole-terminated poly(ethylene glycol) (peg-bm) and beta-cyclodextrin-modified poly(l-lactide) (cd-plla) were developed by exploiting the hostguest interaction between benzimidazole (bm) and beta-cyclodextrin (beta-cd). the dissociation of the supramolecular micelles was triggered in acidic environments. an antineoplastic drug, doxorubicin (dox), was loaded into the supramolecular micelles as a model drug. the release of dox from the supramolecular micelles was clearly accelerated as the ph was reduced from 7.4 to 5.5. the dox-loaded peg-bm/cd-plla supramolecular micelles displayed an enhanced intracellular drug-release rate in hepg2 cells compared to the ph-insensitive dox-loaded peg-b-plla counterpart. after intravenous injection into nude mice bearing hepg2 xenografts by the tail vein, the dox-loaded supramolecular micelles exhibited significantly higher tumor inhibition efficacy and reduced systemic toxicity compared to free dox. furthermore, the dox-loaded supramolecular micelles showed a blood clearance rate markedly lower than that of free dox and comparable to that of the dox-loaded peg-b-plla micelles after intravenous injection into rats. therefore, the ph-responsive peg-bm/cd-plla supramolecular micelles hold potential as a smart nanocarrier for anticancer drug delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64745]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang,Zhe,Lv,Qiang,Gao,Xiaoye,et al. pH-Responsive Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest Interaction[J]. acs applied materials & interfaces,2015,7(16):8404-8411. |
| APA | Zhang,Zhe.,Lv,Qiang.,Gao,Xiaoye.,Chen,Li.,Cao,Yue.,...&Chen,Xuesi.(2015).pH-Responsive Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest Interaction.acs applied materials & interfaces,7(16),8404-8411. |
| MLA | Zhang,Zhe,et al."pH-Responsive Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest Interaction".acs applied materials & interfaces 7.16(2015):8404-8411. |
入库方式： OAI收割
来源：长春应用化学研究所
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