One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
文献类型：期刊论文
| 作者 | Zheng,Min; Liu,Shi; Guan,Xingang; Xie,Zhigang |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:40页码:22181-22187 |
| 关键词 | METAL-ORGANIC FRAMEWORKS COORDINATION POLYMERS CO2 CAPTURE NANOPARTICLES CELLS RELEASE ENCAPSULATION PH DELIVERY STORAGE |
| 通讯作者 | xie,zg |
| 英文摘要 | a straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (ccm)-loaded nanoscale zeolitic imidazolate framework-8 (ccm@nzif-8) nanopartides (nps). the as-synthesized ccm@nzif-8 nps possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. confocal laser scanning microscopy and cytotoxicity experiments reveal that nzif-8 based nanocarriers promote the cellular uptake of ccm and result in higher cytotoxicity of ccm@nzif-8 than that of free ccm toward hela cells. the in vivo anticancer experiments indicate that ccm@nzif-8 nps exhibit much higher antitumor efficacy than free ccm. this work highlights the potential of using nanoscale metal organic framworks (nmofs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000363001500009 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64755]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zheng,Min,Liu,Shi,Guan,Xingang,et al. One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer[J]. acs applied materials & interfaces,2015,7(40):22181-22187. |
| APA | Zheng,Min,Liu,Shi,Guan,Xingang,&Xie,Zhigang.(2015).One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer.acs applied materials & interfaces,7(40),22181-22187. |
| MLA | Zheng,Min,et al."One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer".acs applied materials & interfaces 7.40(2015):22181-22187. |
入库方式： OAI收割
来源：长春应用化学研究所
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