Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment
文献类型：期刊论文
| 作者 | Ma,Hecheng; He,Chaoliang; Cheng,Yilong; Yang,Zhiming; Zang,Junting; Liu,Jianguo; Chen,Xuesi |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:49页码:27040-27048 |
| 关键词 | STUDY-GROUP PROTOCOLS BLOCK-COPOLYMER INJECTABLE HYDROGELS SUSTAINED-RELEASE DRUG-DELIVERY BREAST-CANCER CELL-DEATH CHEMOTHERAPY THERAPY COMBINATION |
| 通讯作者 | he,cl |
| 英文摘要 | localized cancer treatments with combination drugs have recently emerged as crucial approaches for effective inhibition of tumor growth and reoccurrence. in this study, we present a new strategy for the osteosarcoma treatment by localized co-delivery of multiple drugs, including doxorubicin (dox), cisplatin (cddp) and methotraxate (mtx), using thermosensitive plga peg plga hydrogels. the release profiles of the drugs from the hydrogels were investigated in vitro. it was found that the multidrug coloaded hydrogels exhibited synergistic effects on cytoto]dcity against osteosarcoma saos-2 and mg-63 cells in vitro. after a single peritumoral injection of the drug-loaded hydrogels into nude mice bearing human osteosarcoma saos-2 xenografts, the hydrogels coloaded with dox, cddp, and mtx displayed the highest tumor suppression efficacy in vivo for up to 16 days, as well as led to enhanced tumor apoptosis and increased regulation of the expressions of apoptosis-related genes. moreover, the monitoring on the mice body change and the ex vivo histological analysis of the key organs indicated that the localized treatments caused less systemic toxicity and no obvious damage to the normal organs. therefore, the approach of localized co-delivery of dox, cddp, and mtx by the thermosensitive hydrogels may be a promising approach for enhanced osteosarcoma treatment. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366873900004 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64761]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ma,Hecheng,He,Chaoliang,Cheng,Yilong,et al. Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment[J]. acs applied materials & interfaces,2015,7(49):27040-27048. |
| APA | Ma,Hecheng.,He,Chaoliang.,Cheng,Yilong.,Yang,Zhiming.,Zang,Junting.,...&Chen,Xuesi.(2015).Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment.acs applied materials & interfaces,7(49),27040-27048. |
| MLA | Ma,Hecheng,et al."Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment".acs applied materials & interfaces 7.49(2015):27040-27048. |
入库方式： OAI收割
来源：长春应用化学研究所
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