Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice
文献类型：期刊论文
| 作者 | Liu,Shi; Wang,Xue; Zhang,Zhiyun; Zhang,Yan; Zhou,Guangyuan; Huang,Yubin; Xie,Zhigang; Jing,Xiabin |
| 刊名 | nanomedicine-nanotechnology biology and medicine
 |
| 出版日期 | 2015 |
| 卷号 | 11期号:5页码:1047-1056 |
| 关键词 | HEPATOCELLULAR-CARCINOMA ELECTROSPUN THERAPY |
| 通讯作者 | zhou,gy |
| 英文摘要 | local tumor recurrence remains a major clinical problem following surgical treatment for most cancers such as hepatocellular carcinoma (hcc). an implantable local drug delivery system may be suitable for addressing this unmet clinical need. in this study, asymmetric multilayer polylactide nanofiber (ampn) mats were prepared and a one-sided and prolonged release profile of hydrophilic dye or oxaliplatin was observed after they were sandwiched between two liver lobes in mice. covering the surgery site by drug-loaded ampn mat after tumor resection, in both subcutaneous and orthotopic hcc model in mice, the recurrence of hcc was significantly retarded and the survival time of mice was markedly prolonged. in conclusion, post-surgical therapy at tumor resection margins by drug-loaded ampn mats may represent a suitable application of nanofiber-based local chemotherapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000363967100002 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64798]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu,Shi,Wang,Xue,Zhang,Zhiyun,et al. Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice[J]. nanomedicine-nanotechnology biology and medicine,2015,11(5):1047-1056. |
| APA | Liu,Shi.,Wang,Xue.,Zhang,Zhiyun.,Zhang,Yan.,Zhou,Guangyuan.,...&Jing,Xiabin.(2015).Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice.nanomedicine-nanotechnology biology and medicine,11(5),1047-1056. |
| MLA | Liu,Shi,et al."Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice".nanomedicine-nanotechnology biology and medicine 11.5(2015):1047-1056. |
入库方式： OAI收割
来源：长春应用化学研究所
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