Chirality-mediated polypeptide micelles for regulated drug delivery
文献类型：期刊论文
| 作者 | Ding,Jianxun; Li,Chen; Zhang,Ying; Xu,Weiguo; Wang,Jincheng; Chen,Xuesi |
| 刊名 | acta biomaterialia
 |
| 出版日期 | 2015 |
| 卷号 | 11期号:1页码:346-355 |
| 关键词 | BLOCK-COPOLYMER MICELLES POLYMERIC MICELLES BIOMEDICAL APPLICATIONS SECONDARY STRUCTURE CANCER-THERAPY IN-VITRO DOXORUBICIN EFFICACY DESIGN NANOPARTICLES |
| 通讯作者 | chen,xs |
| 英文摘要 | two kinds of triblock poly(ethylene glycol)-polyleucine (peg-pleu) copolymers were synthesized through the ring-opening polymerization of l-leu n-carboxyanhydride (nca), or equivalent d-leu nca and l-leu nca with amino-terminated peg as a macroinitiator. the amphiphilic copolymers spontaneously self-assembled into spherical micellar aggregations in an aqueous environment. the micelle with a racemic polypeptide core exhibited smaller critical micelle concentration and diameter compared to those with a levorotatory polypeptide core. a model anthracycline antineoplastic agent, i.e., doxorubicin (dox), was loaded into micelles through nanoprecipitation, and the peg-p(d,l-leu) micelle exhibited higher drug-loading efficacy than that with a p(l-leu) core this difference was attributed to the flexible and compact p(l-leu) core. sustained in vitro dox release from micelles with both levorotatory and racemic polypeptide cores was observed, and the dox-loaded peg-p(d,l-leu) micelle exhibited a slower release rate. more interestingly, dox-loaded micelles exhibited chirality-mediated antitumor efficacy in vitro and in vivo, which are all better than that of free dox. furthermore, both enhanced tumor inhibition and excellent security in vivo were confirmed by histopathological or in situ cell apoptosis analyses. therefore, dox-loaded peg-pleu micelles appear to be an interesting nanoscale polymeric formulation for promising malignancy chemotherapy. (c) 2014 acta materialia inc. published by elsevier ltd. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64800]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding,Jianxun,Li,Chen,Zhang,Ying,et al. Chirality-mediated polypeptide micelles for regulated drug delivery[J]. acta biomaterialia,2015,11(1):346-355. |
| APA | Ding,Jianxun,Li,Chen,Zhang,Ying,Xu,Weiguo,Wang,Jincheng,&Chen,Xuesi.(2015).Chirality-mediated polypeptide micelles for regulated drug delivery.acta biomaterialia,11(1),346-355. |
| MLA | Ding,Jianxun,et al."Chirality-mediated polypeptide micelles for regulated drug delivery".acta biomaterialia 11.1(2015):346-355. |
入库方式： OAI收割
来源：长春应用化学研究所
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