Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis
文献类型：期刊论文
| 作者 | Li,Mingqiang; Tang,Zhaohui; Zhang,Yu; Lv,Shixian; Li,Quanshun; Chen,Xuesi |
| 刊名 | acta biomaterialia
 |
| 出版日期 | 2015 |
| 卷号 | 18期号:12页码:132-143 |
| 关键词 | CELL LUNG-CANCER DRUG-DELIVERY IN-VIVO CO-DELIVERY ANTITUMOR EFFICACY TUMOR-GROWTH DOXORUBICIN THERAPY PACLITAXEL INHIBITION |
| 通讯作者 | chen,xs |
| 英文摘要 | the metastasis of breast cancer is the leading cause of cancer death in women. in this work, an attempt to simultaneously inhibit the primary tumor growth and organ-specific metastasis by the cisplatin-loaded lhrh-modified dextran nanoparticles (dex-sa-cddp-lhrh) was performed in the 4t1 orthotopic mammary tumor metastasis model. with the rationally designed conjugation site of the lhrh ligand, the dex-sa-cddp-lhrh nanoparticles maintained the targeting function of lhrh and specifically bound to the lhrh-receptors overexpressed on the surface of 4t1 breast cancer cells. therefore, the dex-sa-cddp-lhrh nanoparticles exhibited improved cellular uptake and promoted cytotoxicity, when compared with the non-targeted dex-sa-cddp nanoparticles. moreover, both the non-targeted and targeted nanoparticles significantly decreased the systemic toxicity of cddp and increased the maximum tolerated dose of cddp from 4 to 30 mg kg(-1). importantly, dex-sa-cddp-lhrh markedly enhanced the accumulation of cddp in the injected primary tumor and metastasis-containing organs, and meanwhile significantly reduced the nephrotoxicity of cddp. dose-dependent therapeutic effects further demonstrated that the cddp-loaded lhrh-decorated polysaccharide nanoparticles significantly enhanced the antitumor and antimetastasis efficacy, as compared to the non-targeted nanoparticles. these results suggest that dex-sa-cddp-lhrh nanoparticles show great potential for targeted chemotherapy of metastatic breast cancer. (c) 2015 acta materialia inc. published by elsevier ltd. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64801]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li,Mingqiang,Tang,Zhaohui,Zhang,Yu,et al. Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis[J]. acta biomaterialia,2015,18(12):132-143. |
| APA | Li,Mingqiang,Tang,Zhaohui,Zhang,Yu,Lv,Shixian,Li,Quanshun,&Chen,Xuesi.(2015).Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis.acta biomaterialia,18(12),132-143. |
| MLA | Li,Mingqiang,et al."Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis".acta biomaterialia 18.12(2015):132-143. |
入库方式： OAI收割
来源：长春应用化学研究所
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