Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment
文献类型：期刊论文
| 作者 | Chen,Jie; Dong,Xuan; Feng,Tianshi; Lin,Lin; Guo,Zhaopei; Xia,Jialiang; Tian,Huayu; Chen,Xuesi |
| 刊名 | acta biomaterialia
 |
| 出版日期 | 2015 |
| 卷号 | 26期号:20页码:45-53 |
| 关键词 | GENE TRANSFECTION SIRNA DELIVERY IN-VIVO CARRIERS THERAPY EFFICIENT NANOPARTICLES CELLS POLYETHYLENIMINE METASTASIS |
| 通讯作者 | tian,hy |
| 英文摘要 | a novel ph-responsive gene delivery system for tumor acidity-targeted pdna delivery is prepared by introducing a rapid charge-conversional zwitterionic copolymer to the positive surface of pei/pdna complexes through electrostatic interaction. the shielding system (oeal) consists of oligoethylenimine (oei), poly(l-aspartate) (pbla), and poly(l-lysine) (pll). the charge-conversional behavior of the oeal/pei/dna ternary complex is evaluated by zeta potential assay. the surface charges of the complexes can change from negative to positive in the ph range of 7.4-6.8. under a simulative in vivo environment, oeal/pei/dna exhibits promotion of cellular uptake by tumor cells and enhanced gene transfection efficiency because of its good charge-conversional properties. antitumor experiments further show that the ph-responsive charge-conversional system can mediate a therapeutic gene that can induce tumor apoptosis (pkh3-rev-casp-3) to achieve effective tumor inhibition. accordingly, oeal can be regarded as a promising tumor microenvironment-sensitive gene delivery shielding system for antitumor therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362917200005 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64803]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen,Jie,Dong,Xuan,Feng,Tianshi,et al. Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment[J]. acta biomaterialia,2015,26(20):45-53. |
| APA | Chen,Jie.,Dong,Xuan.,Feng,Tianshi.,Lin,Lin.,Guo,Zhaopei.,...&Chen,Xuesi.(2015).Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment.acta biomaterialia,26(20),45-53. |
| MLA | Chen,Jie,et al."Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment".acta biomaterialia 26.20(2015):45-53. |
入库方式： OAI收割
来源：长春应用化学研究所
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