pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent
文献类型：期刊论文
| 作者 | Sun,Diankui; Ding,Jianxun; Xiao,Chunsheng; Chen,Jinjin; Zhuang,Xiuli; Chen,Xuesi |
| 刊名 | advanced healthcare materials
 |
| 出版日期 | 2015 |
| 卷号 | 4期号:6页码:844-855 |
| 关键词 | DRUG-DELIVERY SYSTEM CANCER-THERAPY POLYMERIC MICELLES DOXORUBICIN NANOPARTICLES RELEASE RESISTANCE REDUCTION CHEMISTRY NANOGELS |
| 通讯作者 | ding,jx |
| 英文摘要 | the reversible pegylation endows antitumor drugs with various fascinating advantages, including prolonged circulation time in blood, enhanced accumulation in tumor tissue, increased cellular uptake, and promoted intracellular drug release, to improve the therapeutic efficacy and security. here, the obtained succinic anhydride (sa)-functionalized dox (sad) (i.e., insensitive succinic anhydride-functionalized doxorubicin (dox)) and aconitic anhydride (ca)-modified dox (cad) (i.e., acid-sensitive cis-aconitic anhydride-modified dox) are conjugated to the terminal of poly(ethylene glycol) (peg) yielding the unresponsive sad-peg-sad and ph-responsive cad-peg-cad prodrugs, respectively. the prepared prodrugs can self-assemble into micelles in aqueous solution. both micelles are sufficiently stable at normal physiological ph (i.e., 7.4), while cad-peg-cad micelle gradually swells and finally disassembles at intratumoral (i.e., 6.8) and especially endosomal phs (i.e., 5.5). dox release from cad-peg-cad at ph 7.4 is efficiently inhibited, whereas it is significantly accelerated by the rapid cleavage of amide bond at ph 5.5. in addition, cad-peg-cad exhibits more efficient cellular uptake and potent cytotoxicity in vitro, as well as improved tissue distribution and superior tumor suppression in vivo than free dox and sad-peg-sad. more importantly, the pegylated dox exhibits favorable security in vivo. in brief, the smart cad-peg-cad with enhanced antitumor efficacy and decreased side effects shows as a promising powerful platform for the clinical chemotherapy of malignancy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64818]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun,Diankui,Ding,Jianxun,Xiao,Chunsheng,et al. pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent[J]. advanced healthcare materials,2015,4(6):844-855. |
| APA | Sun,Diankui,Ding,Jianxun,Xiao,Chunsheng,Chen,Jinjin,Zhuang,Xiuli,&Chen,Xuesi.(2015).pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent.advanced healthcare materials,4(6),844-855. |
| MLA | Sun,Diankui,et al."pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent".advanced healthcare materials 4.6(2015):844-855. |
入库方式： OAI收割
来源：长春应用化学研究所
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