Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy
文献类型：期刊论文
| 作者 | Xiong,Hejian; Zhou,Dongfang; Qi,Yanxin; Zhang,Zhiyun; Xie,Zhigang; Chen,Xuesi; Jing,Xiabin; Meng,Fanbo; Huang,Yubin |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:12页码:3980-3988 |
| 关键词 | NEUTRON-CAPTURE THERAPY DRUG-DELIVERY DIHYDROGEN BONDS CLICK CHEMISTRY BORON MICELLES METALLACARBORANES LIPOSOMES CARRIERS CELLS |
| 通讯作者 | meng,fb |
| 英文摘要 | carborane-conjugated amphiphilic copolymer nanoparticles were designed to deliver anticancer drugs for the combination of chemotherapy and boron neutron capture therapy (bnct). poly(ethylene glycol)-b-poly(l-lactide-co-2-methyl-2 (2-dicarba-closo-dodecarborane) propyloxycarbonyl-propyne carbonate) (plmb) was synthesized via the versatile reaction between decaborane and side alkynyl groups, and self-assembled with doxorubicin (dox) to form drug-loaded nanoparticles. these dox@plmb nanoparticles could not only suppress the leakage of the boron compounds into the bloodstream due to the covalent bonds between carborane and polymer main chains, but also protect dox from initial burst release at physiological conditions because of the dihydrogen bonds between dox and carborane. it was demonstrated that dox@plmb nanoparticles could selectively deliver boron atoms and dox to the tumor site simultaneously in vivo. under the combination of chemotherapy and bnct, the highest tumor suppression efficiency without reduction of body weight was achieved. this polymeric nanoparticles delivery system could be very useful in future chemoradiotherapy to obtain improved therapeutic effect with reduced systemic toxicity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366616700028 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64821]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiong,Hejian,Zhou,Dongfang,Qi,Yanxin,et al. Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy[J]. biomacromolecules,2015,16(12):3980-3988. |
| APA | Xiong,Hejian.,Zhou,Dongfang.,Qi,Yanxin.,Zhang,Zhiyun.,Xie,Zhigang.,...&Huang,Yubin.(2015).Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy.biomacromolecules,16(12),3980-3988. |
| MLA | Xiong,Hejian,et al."Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy".biomacromolecules 16.12(2015):3980-3988. |
入库方式： OAI收割
来源：长春应用化学研究所
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