Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release
文献类型：期刊论文
| 作者 | Xiao,chunsheng; Ding,Jianxun; Ma,Lili; Yang,Chenguang; Zhuang,Xiuli; Chen,Xuesi |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:5页码:738-747 |
| 关键词 | BIOMEDICAL APPLICATIONS POLY(ETHYLENE GLYCOL) CANCER-CELLS L-CYSTEINE DELIVERY POLYPEPTIDES WATER MICELLES POLY(BETA-THIOESTER)S POLYMERIZATION |
| 通讯作者 | chen,xs |
| 英文摘要 | we demonstrated herein a kind of thermal and oxidation dual responsive polymer with a novel structure of alternating hydrophilic and hydrophobic segments in the backbone. the polymers were facilely synthesized by thiol-ene polymerization of poly(ethylene glycol) diacrylate (pegda) and 1,2-ethanedithiol (edt) monomers. the resulting peg-edt copolymers exhibited a sharp and reversible thermal-induced phase transition in aqueous medium which was identified to be caused by the cooperativity of dehydration of peg segments and the increased hydrophobic interaction between beta-thioether ester segments in the backbone. additionally, the cloud point temperatures of peg-edt copolymers were examined to be dependent on the molecular weight of peg, polymer concentration, addition of nacl and isotopic solvent. more importantly, the peg-edt copolymers were tested to be oxidation sensitive due to the presence of oxidizable thioether groups in the backbone. the collapsed polymers at elevated temperatures could be easily converted into completely water-soluble polymers by oxidative conversion of hydrophobic thioether groups into hydrophilic sulfoxide and sulfone groups. this oxidation-switchable water solubility inspired us to use this copolymer in design of the oxidation-triggered drug delivery system. thus, a triblock copolymer mpeg-b-575edt-b-mpeg was synthesized by a one-pot method. the resulting triblock copolymer could self-assemble into nanoparticles using thermal and oxidation dual responsive 575-edt as the core and mpeg as the shell. as a consequence, the hydrophobic model drug (i.e., nile red) can be effectively encapsulated into the collapsed nanoparticle core at the body temperature while released by oxidation-triggered disruption of the nanoparticles. this tunable thermo-responsive behavior in combination with oxidation-triggerable thioether groups makes these peg-edt copolymers promising for reactive oxygen species (ros) responsive drug delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64854]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao,chunsheng,Ding,Jianxun,Ma,Lili,et al. Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release[J]. polymer chemistry,2015,6(5):738-747. |
| APA | Xiao,chunsheng,Ding,Jianxun,Ma,Lili,Yang,Chenguang,Zhuang,Xiuli,&Chen,Xuesi.(2015).Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release.polymer chemistry,6(5),738-747. |
| MLA | Xiao,chunsheng,et al."Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release".polymer chemistry 6.5(2015):738-747. |
入库方式： OAI收割
来源：长春应用化学研究所
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