epsilon-Methacryloyl-L-lysine based polypeptides and their thiol-ene click functionalization
文献类型：期刊论文
| 作者 | Xu,Qinghua; He,Chaoliang; Xiao,Chunsheng; Yu,Shuangjiang; Chen,Xuesi |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:10页码:1758-1767 |
| 关键词 | RING-OPENING POLYMERIZATION ACID N-CARBOXYANHYDRIDES SYNTHETIC POLYPEPTIDES RADICAL POLYMERIZATION CHEMISTRY CONFORMATIONS BACKBONE POLYMERS |
| 通讯作者 | he,cl |
| 英文摘要 | facile synthesis of biopolymers that facilitate versatile post-polymerization modification is of great interest for biotechnological and biomedical applications. in this study, a methacryloyl-substituted l-lysine n-carboxyanhydride (lysma-nca) monomer was designed and synthesized, and methacryloyl-functionalized polypeptides were prepared through the ring opening polymerization (rop) of the l-lysine-based monomer. the post-polymerization functionalization of the methacryloyl-containing polypeptides with various thiol-containing molecules was achieved with high efficiency through facile radical-mediated thiol-ene chemistry. moreover, a block copolypeptide bearing both methacryloyl and alkynyl pendants was developed through successive rop of lysma-nca and gamma-propargyl-l-glutamate (pplg-nca). the sequential modification of the block copolypeptide with hydrophilic and hydrophobic molecules, respectively, was achieved by the successive alkyne-azido and thiol-ene "click" reactions. overall, the facile synthesis of polypeptides bearing functional substituents and their versatile post-polymerization modification may serve as a useful platform for the development of various functional polymers. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350641400010 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64858]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu,Qinghua,He,Chaoliang,Xiao,Chunsheng,et al. epsilon-Methacryloyl-L-lysine based polypeptides and their thiol-ene click functionalization[J]. polymer chemistry,2015,6(10):1758-1767. |
| APA | Xu,Qinghua,He,Chaoliang,Xiao,Chunsheng,Yu,Shuangjiang,&Chen,Xuesi.(2015).epsilon-Methacryloyl-L-lysine based polypeptides and their thiol-ene click functionalization.polymer chemistry,6(10),1758-1767. |
| MLA | Xu,Qinghua,et al."epsilon-Methacryloyl-L-lysine based polypeptides and their thiol-ene click functionalization".polymer chemistry 6.10(2015):1758-1767. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。