Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery
文献类型：期刊论文
| 作者 | Kuang,Huihui; Wu,Yanjuan; Zhang,Zhiyun; Li,Jizhen; Chen,Xuesi; Xie,Zhigang; Jing,Xiabin; Huang,Yubin |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:19页码:3625-3633 |
| 关键词 | POLYMERIC MICELLES ANTICANCER DRUGS GENE DELIVERY RELEASE NANOPARTICLES PARTICLES BLOCK CISPLATIN(IV) THERAPEUTICS DOXORUBICIN |
| 通讯作者 | huang,yb |
| 英文摘要 | a double ph-responsive supramolecular copolymer micelle was successfully developed, which was based on complementary multiple hydrogen bonds of nucleobases and acetalated dextran. the thymine-terminated poly(ethylene glycol) (t-peg-t) and adenine-terminated acetalated dextran (acdex-a) were synthesized and used to construct supramolecular amphiphilic triblock copolymer acdex-a: t-peg-t: a-acdex, which could be further self-assembled into supramolecular micelles in water. these micelles were stable at ph 7.4, but disruptive at ph 5.0 due to the double ph-sensitivity of hydrogen bonds within the copolymer backbones and the hydrolysis of the acetalated dextran. the hydroxyl coverage of ac-dex had an important effect on the critical micelle concentration (cmc) and particle size of acdex-a: t-peg-t: a-acdex micelles, which were observed by transmission electron microscopy (tem) and dynamic light scattering (dls). in addition, turbidometry was utilized to evaluate the effect of ph-responsivity of acdex-a: t-peg-t: a-acdex micelles and these supramolecular micelles were completely decomposed at ph 5.0. cytotoxicity evaluation showed good biocompatibility of these micelles, and doxorubicin (dox) was encapsulated into supramolecular micelles as a model drug. the in vitro drug release profile showed that the dox release speed at ph 5.0 could be adjusted by changing the hydroxyl coverage of ac-dex. meanwhile, dox-loaded supramolecular micelles could be efficiently internalized into cancer cells and showed similar inhibition of proliferation of the hela cell as free dox. this work provided a new method for enabling a rapid intracellular release of drugs by using double ph-sensitive hydrogen bonds and acetalated dextran, which would have the potential to be applied in controlled drug delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64860]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kuang,Huihui,Wu,Yanjuan,Zhang,Zhiyun,et al. Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery[J]. polymer chemistry,2015,6(19):3625-3633. |
| APA | Kuang,Huihui.,Wu,Yanjuan.,Zhang,Zhiyun.,Li,Jizhen.,Chen,Xuesi.,...&Huang,Yubin.(2015).Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery.polymer chemistry,6(19),3625-3633. |
| MLA | Kuang,Huihui,et al."Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery".polymer chemistry 6.19(2015):3625-3633. |
入库方式： OAI收割
来源：长春应用化学研究所
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