rVarBase: an updated database for regulatory features of human variants
文献类型：期刊论文
| 作者 | Guo, Liyuan1 ; Du, Yang1,2; Qu, Susu1,2; Wang, Jing1
|
| 刊名 | NUCLEIC ACIDS RESEARCH
 |
| 出版日期 | 2016-01-04 |
| 卷号 | 44期号:D1页码:D888-D893 |
| ISSN号 | 0305-1048 |
| 英文摘要 | We present here the rVarBase database (http://rv.psych.ac.cn), an updated version of the rSNPBase database, to provide reliable and detailed regulatory annotations for known and novel human variants. This update expands the database to include additional types of human variants, such as copy number variations (CNVs) and novel variants, and include additional types of regulatory features. Now rVarBase annotates variants in three dimensions: chromatin states of the surrounding regions, overlapped regulatory elements and variants' potential target genes. Two new types of regulatory elements (lncRNAs and miRNA target sites) have been introduced to provide additional annotation. Detailed information about variants' overlapping transcription factor binding sites (TFBSs) (often less than 15 bp) within experimentally supported TF-binding regions (similar to 150 bp) is provided, along with the binding motifs of matched TF families. Additional types of extended variants and variant-associated phenotypes were also added. In addition to the enrichment in data content, an element-centric search module was added, and the web interface was refined. In summary, rVarBase hosts more types of human variants and includes more types of up-to-date regulatory information to facilitate in-depth functional research and to provide practical clues for experimental design. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | GENOMIC STRUCTURAL VARIATION ; GENE-EXPRESSION ; HUMAN-DISEASE ; INTEGRATIVE ANALYSIS ; ASSOCIATIONS ; RESOURCE ; TARGETS ; ANNOTATION ; INSIGHTS ; PROJECT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371261700126 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19689]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Liyuan,Du, Yang,Qu, Susu,et al. rVarBase: an updated database for regulatory features of human variants[J]. NUCLEIC ACIDS RESEARCH,2016,44(D1):D888-D893. |
| APA | Guo, Liyuan,Du, Yang,Qu, Susu,&Wang, Jing.(2016).rVarBase: an updated database for regulatory features of human variants.NUCLEIC ACIDS RESEARCH,44(D1),D888-D893. |
| MLA | Guo, Liyuan,et al."rVarBase: an updated database for regulatory features of human variants".NUCLEIC ACIDS RESEARCH 44.D1(2016):D888-D893. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。