Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth
文献类型：期刊论文
| 作者 | Wang, Chunxiang; Ding, Xiao; Feng, Shi-Xiu; Guan, Qiunong; Zhang, Xiao-Ping; Du, Caigan; Di, Ying-Tong ; Chen, Tao
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2015-12-01 |
| 卷号 | 20期号:12页码:22565-22577 |
| 关键词 | natural compound Prismatomeris connata tetrahydroanthraquinones prisconnatanones C-I HPLC-NMR anti-tumor activity |
| 英文摘要 | The root of Prismatomeris connata has been used in China for centuries as the medicinal herb Huang Gen (HG), but its phytochemicals or active ingredients are not well understood. In this study, we performed chemical analysis of the ethyl acetate fraction of a HG ethanol extract. We thus isolated seven new tetrahydroanthraquinones, prisconnatanones C-I (compounds 1-7) from the root of P. connata and identified their structures using spectroscopic analyses. Their absolute configurations were established by both modified Mosher's and Mo2OAc4 methods, and ORD techniques. Their cytotoxicity was tested in a panel of human lung tumor cells (H1229, HTB179, A549 and H520 cell lines). Prisconnatanone I (7) showed the highest activity, with an IC50 value ranging from 2.7 mu M to 3.9 mu M in the suppression of tumor cell growth, and the others with chelated phenolic hydroxyls exhibited relatively lower activity (IC50: 8-20 mu M). In conclusion, these data suggest that some of the natural tetrahydroanthraquinones in HG are bioactive, and hydroxylation at C-1 significantly increases the cytotoxicity of these compounds against lung tumor cell growth. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ANTHRAQUINONES ; GLYCOSIDES ; TETRANDRA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367533400117 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25435]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Chunxiang,Ding, Xiao,Feng, Shi-Xiu,et al. Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth[J]. MOLECULES,2015,20(12):22565-22577. |
| APA | Wang, Chunxiang.,Ding, Xiao.,Feng, Shi-Xiu.,Guan, Qiunong.,Zhang, Xiao-Ping.,...&Chen, Tao.(2015).Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth.MOLECULES,20(12),22565-22577. |
| MLA | Wang, Chunxiang,et al."Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth".MOLECULES 20.12(2015):22565-22577. |
入库方式： OAI收割
来源：昆明植物研究所
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