Polyethyleneimine-modified graphene oxide nanocomposites for effective protein functionalization
文献类型：期刊论文
| 作者 | Weng, Yejing1,2; Jiang, Bo1; Yang, Kaiguang1; Sui, Zhigang1; Zhang, Lihua1; Zhang, Yukui1 |
| 刊名 | nanoscale
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:34页码:14284-14291 |
| 通讯作者 | 张丽华 |
| 英文摘要 | a facile method to prepare a biocompatible graphene oxide (go)-based substrate for protein immobilization was developed to overcome the drawbacks of go, such as the strong electrostatic and hydrophobic interactions which could potentially alter the conformation and biological activity of proteins. the go was coated with hydrophilic branched polyethyleneimine (bpei), while concanavalin a (con a) as a model lectin protein was employed to fabricate the functionalized composites to evaluate the feasibility of this strategy. the composites exhibit an extremely high binding capacity for glycoproteins (i.e. igg 538.3 mg g(-1)), which are superior to other immobilized materials. moreover, they can work well in 500-fold non-glycoprotein interference and even in complex biological samples. all these data suggest that the go@bpei composites will have great potential as scaffolds for proteins fully exerting their biofunctions. |
| 学科主题 | 物理化学 |
| WOS标题词 | science & technology ; physical sciences ; technology |
| 类目[WOS] | chemistry, multidisciplinary ; nanoscience & nanotechnology ; materials science, multidisciplinary ; physics, applied |
| 研究领域[WOS] | chemistry ; science & technology - other topics ; materials science ; physics |
| 关键词[WOS] | concanavalin-a ; enzyme immobilization ; selective enrichment ; glycoproteins ; matrix ; nanoparticles ; glycosylation ; nanosheets ; reduction ; graphite |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360117200012 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/143725]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Weng, Yejing,Jiang, Bo,Yang, Kaiguang,et al. Polyethyleneimine-modified graphene oxide nanocomposites for effective protein functionalization[J]. nanoscale,2015,7(34):14284-14291. |
| APA | Weng, Yejing,Jiang, Bo,Yang, Kaiguang,Sui, Zhigang,Zhang, Lihua,&Zhang, Yukui.(2015).Polyethyleneimine-modified graphene oxide nanocomposites for effective protein functionalization.nanoscale,7(34),14284-14291. |
| MLA | Weng, Yejing,et al."Polyethyleneimine-modified graphene oxide nanocomposites for effective protein functionalization".nanoscale 7.34(2015):14284-14291. |
入库方式： OAI收割
来源：大连化学物理研究所
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