Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2
文献类型：期刊论文
| 作者 | Li, Yao-Guang1,2; Hou, Jie3; Li, Shi-Yang1; Lv, Xia1; Ning, Jing1,3; Wang, Ping1; Liu, Zhao-Ming1; Ge, Guang-Bo1; Ren, Jia-Yan2; Yang, Ling1 |
| 刊名 | fitoterapia
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 101期号:1页码:99-106 |
| 关键词 | Fructus Psoraleae Human carboxylesterase 2 Inhibitory effects LC-DAD-ESI-MS/MS |
| 通讯作者 | 葛广波 ; jia-yanren ; 杨凌 |
| 英文摘要 | fructus psoraleae (fp) is an edible chinese herbal which is widely used in asia for the treatment of various diseases including asthma, diarrhea, and osteoporosis. this study aimed to investigate the inhibitory effects of the crude ethanol extract from fp on human carboxylesterase 2 (hce2), as well as to identity and characterize the naturally occurring inhibitors of hce2 in fp. our results demonstrated that the ethanol extract of fp displayed potent inhibitory effects towards hce2, while five major bioactive constitutes in fp were efficiently identified by lc-dad-esi-ms/ms, with the aid of lc-based activity profiling. the identified bioactive compounds including neobavaisoflavone, isobavachalcone, bavachinin, corylifol a and bakuchiol were found to be naturally occurring potent inhibitors of hce2, with low ki values ranging from 0.62 mu m to 3.89 mu m. this is the first report of the chemical constitutes in fp as potent inhibitors of hce2. (c) 2015 elsevier b.v. all rights reserved. |
| 学科主题 | 物理化学 |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | performance liquid-chromatography ; catalytic-properties ; fluorescent-probe ; bakuchiol ; irinotecan ; cpt-11 ; constituents ; hydrolysis ; activation ; components |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352252700014 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/143758]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China 3.Dalian Med Univ, Dalian 116044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yao-Guang,Hou, Jie,Li, Shi-Yang,et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2[J]. fitoterapia,2015,101(1):99-106. |
| APA | Li, Yao-Guang.,Hou, Jie.,Li, Shi-Yang.,Lv, Xia.,Ning, Jing.,...&Yang, Ling.(2015).Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2.fitoterapia,101(1),99-106. |
| MLA | Li, Yao-Guang,et al."Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2".fitoterapia 101.1(2015):99-106. |
入库方式： OAI收割
来源：大连化学物理研究所
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