A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography
文献类型：期刊论文
| 作者 | Zhang, Haiyang1,2; Ou, Junjie2; Wei, Yinmao1; Wang, Hongwei2,3; Liu, Zhongshan2,3; Chen, Lianfang2,3 ; Zou, Hanfa2
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| 刊名 | analytica chimica acta
 |
| 出版日期 | 2015-07-09 |
| 卷号 | 883期号:1页码:90-98 |
| 关键词 | Polymer monoliths Capillary liquid chromatography Dipentaerythritol penta-/hexa-acrylate Photo-initiated polymerization |
| 通讯作者 | 欧俊杰 ; 卫引茂 ; 邹汉法 |
| 英文摘要 | low column efficiency for small molecules in reversed-phase chromatography is a major problem commonly encountered in polymer-based monoliths. herein, a novel highly crosslinked porous polymeric monolith was in situ prepared by using a multi-acrylate monomer, dipentaerythritol penta-/hexa-acrylate (dpepa), as crosslinker, which copolymerized with lauryl methacrylate (lma) as functional monomer in a uv-transparent fused-silica capillary via photo-initiated free-radical polymerization within 5 min. the mechanical stability and permeability of the resulting poly(lma-co-dpepa) monolith were characterized in detail. one series of highly crosslinked poly(lma-co-dpepa) columns were prepared with relatively higher content of crosslinker (63.3%) in the precursor. although they exhibited lower permeability, high column efficiency for alkylbenzenes was acquired in clc, and the minimum plate height (column b) was in the range of 6.04-9.00 mm, corresponding to 111,000-165,000 n m(-1). meanwhile, another series of poly(lma-co-dpepa) columns prepared with relatively lower content of crosslinker (52.7%) in the precursor exhibited higher permeability, but the minimum plate height (column e) was relatively low in the range of 10.75-20.04 mm for alkylbenzenes, corresponding to 50,000-93,000 n m(-1). compared with common poly(lma-co-edma) columns previously reported, the highly crosslinked poly(lma-co-dpepa) columns using a multi-acrylate monomer as crosslinker possessed remarkably high column efficiency for small molecules in clc. by plotting of plate height (h) of alkylbenzenes versus the linear velocity (u) of mobile phase, the results revealed a retention-independent efficient performance of small molecules in the isocratic elution, indicating that the use of multi-functional crosslinker possibly prevents the generation of gel-like micropores in the poly(lma-co-dpepa) monolith, reducing the mass transfer resistance (c-term). (c) 2015 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | ring-opening polymerization ; less common applications ; large surface-area ; methacrylate monoliths ; stationary phases ; porous properties ; hybrid monolith ; columns ; hplc ; performance |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356236700011 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/143773]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Haiyang,Ou, Junjie,Wei, Yinmao,et al. A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography[J]. analytica chimica acta,2015,883(1):90-98. |
| APA | Zhang, Haiyang.,Ou, Junjie.,Wei, Yinmao.,Wang, Hongwei.,Liu, Zhongshan.,...&Zou, Hanfa.(2015).A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography.analytica chimica acta,883(1),90-98. |
| MLA | Zhang, Haiyang,et al."A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography".analytica chimica acta 883.1(2015):90-98. |
入库方式： OAI收割
来源：大连化学物理研究所
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