Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer
文献类型：期刊论文
| 作者 | Wan, Hao1,2; Zhang, Yi1; Zhang, Weibing2; Zou, Hanfa1 |
| 刊名 | acs applied materials & interfaces
 |
| 出版日期 | 2015-05-13 |
| 卷号 | 7期号:18页码:9608-9618 |
| 关键词 | two-photon imaging dual targeting pH-triggered release chemo-photodynamic synergistic treatment multifunctional nanocarrier |
| 通讯作者 | 张维冰 ; 邹汉法 |
| 英文摘要 | in consideration of the intrinsic complexity of cancer, just being a delivery nanovehicle for the nanocarrier is no longer enough to fulfill requirements of dealing with cancer. in this regard, the multifunctional nanocarrier appears to be an appealing choice in cancer treatment. herein, the novel multifunctional nanocarrier (fe3o4-ns-c3n4@msio(2)-peg-rgd) possessing properties of dual targeting (the peptide- and magnetism-mediated targeting), imaging (one- and two-photon modes), ph-triggered release of loaded anticancer drug, and synergistic treatment (photodynamic therapy (pdt) combined with chemotherapy) are successfully developed. the nanocarrier specifically centralizes within cancer cells with the enhanced amount through the dual targeting ability and is facilely tracked under one- and two-photon imaging modes attributed to the autofluorescence. then, visible light irradiation-induced pdt combined with low ph-triggered chemotherapy synergistically cooperate to efficiently kill cancer cells. following the above process, the multifunctional nanocarrier demonstrates effective inhibition of the growth of a549 and hela cancer cells. the efficient manipulation of fe3o4-ns-c3n4@msio(2)-peg-rgd also implies potential applications of the multifunctional nanocarrier in delivery of different agents. furthermore, it might also broaden the scope of fabrication of the multifunctional nanocarrier for inhibiting the growth of cancer cells. |
| WOS标题词 | science & technology ; technology |
| 学科主题 | 物理化学 |
| 类目[WOS] | nanoscience & nanotechnology ; materials science, multidisciplinary |
| 研究领域[WOS] | science & technology - other topics ; materials science |
| 关键词[WOS] | carbon nitride nanosheets ; modified silica nanoparticles ; core-shell nanocomposites ; phase c3n4 nanosheets ; near-infrared light ; in-vivo ; visible-light ; quantum dots ; photocatalytic activities ; photothermal therapy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354906500033 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/143779]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Hao,Zhang, Yi,Zhang, Weibing,et al. Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer[J]. acs applied materials & interfaces,2015,7(18):9608-9618. |
| APA | Wan, Hao,Zhang, Yi,Zhang, Weibing,&Zou, Hanfa.(2015).Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer.acs applied materials & interfaces,7(18),9608-9618. |
| MLA | Wan, Hao,et al."Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer".acs applied materials & interfaces 7.18(2015):9608-9618. |
入库方式： OAI收割
来源：大连化学物理研究所
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