A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells
文献类型：期刊论文
| 作者 | Qiao, Qinglong1,2; Zhao, Miao2; Lang, Haijing2; Mao, Deqi1,2; Cui, Jingnan1; Xu, Zhaochao1,2 |
| 刊名 | rsc advances
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:49页码:25790-25794 |
| 通讯作者 | 徐兆超 ; 崔京南 |
| 英文摘要 | hydrogen sulfide (h2s) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. h2s can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. in this study, we developed a lysosome-targetable fluorescent probe for the recognition of h2s with considerable fluorescence enhancement. through introducing a lysosome-targetable group 4-(2aminoethyl)-morpholine into the h2s probe n-imide termus of 4-azide-1,8-naphthalimide, the new compound lyso-afp can recognize h2s in lysosomes. this probe emerges as a more biocompatible analysis tool with low poison by-product than reported h2s fluorescent probes. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | 2-photon probe ; live cells ; zinc ; ph ; activation ; mechanisms ; signals ; sensors ; tumors ; zn2+ |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338434500038 |
| 公开日期 | 2016-05-09 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/143918]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Qinglong,Zhao, Miao,Lang, Haijing,et al. A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J]. rsc advances,2014,4(49):25790-25794. |
| APA | Qiao, Qinglong,Zhao, Miao,Lang, Haijing,Mao, Deqi,Cui, Jingnan,&Xu, Zhaochao.(2014).A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells.rsc advances,4(49),25790-25794. |
| MLA | Qiao, Qinglong,et al."A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells".rsc advances 4.49(2014):25790-25794. |
入库方式： OAI收割
来源：大连化学物理研究所
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